Results 211 to 220 of about 8,935,685 (345)

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

How Binding Affinity and Binding Specificity Map to Sequence Space. [PDF]

J Mol Evol
Liberles DA, Meyer MM.
europepmc   +1 more source

Navigating the amino acid sequence space between functional proteins using a deep learning framework. [PDF]

PeerJ Comput Sci, 2021
Bitard-Feildel T.
europepmc   +1 more source

Convergent Sequences in Sequence Spaces

Indagationes Mathematicae (Proceedings), 1957
openaire   +2 more sources

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

SOME PROPERTIES OF MODULAR TOPOLOGY IN THE ORLICZ SEQUENCE SPACE

In this article, we examined some properties of modular topology on the Orlicz sequence space. Discussions were conducted by constructing the topology on the sequence space using a modular neighborhood of zero. The neighborhood forms a local base that is
Haryadi, Haryadi, Solikhin, Solikhin
core   +1 more source

Descent from a common ancestor restricts exploration of protein sequence space. [PDF]

Proc Natl Acad Sci U S A
Isakova LH, Streltsova E, Bochkareva OO, Vlasov PK, Kondrashov FA.   +4 more
europepmc   +1 more source

In Silico Identification of Potential Sites for a Plastic-Degrading Enzyme by a Reverse Screening through the Protein Sequence Space and Molecular Dynamics Simulations. [PDF]

Molecules, 2022
Charupanit K, Tipmanee V, Sutthibutpong T, Limsakul P.   +3 more
europepmc   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

MODULARED SEQUENCE SPACES

Hokkaido Mathematical Journal, 1954
openaire   +3 more sources