Results 131 to 140 of about 2,334,123 (318)

Modelling stem cell differentiation related processes—A practical overview for biologists

open access: yesFEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar   +4 more
wiley   +1 more source

Wide spread of OXA-48-producing Enterobacteriaceae in Algerian hospitals: A four years’ study

open access: yesJournal of Infection in Developing Countries, 2018
Introduction: The aim of this study was to investigate the presence of carbapenemase-producing Enterobacteriaceae (CPE) in Algerian hospitals and to characterize the molecular types of carbapenemases found.
Nadjet Aggoune   +8 more
doaj   +1 more source

Type-sequences of modules

open access: yesJournal of Pure and Applied Algebra, 2001
Let \(R\) be a Noetherian complete local domain of dimension \(1\). In the present paper, the authors define the type sequence \([r_1, \dots, r_n]\) of a fractional ideal \(M\) of \(R\), where \(r_1\) is the Cohen-Macaulay type of \(M\), and they investigate its behavior.
ONETO, ANNA, ZATINI, ELSA
openaire   +2 more sources

Application of sequence stratigraphic concepts to the cretaceous Urgonian carbonate platform, southeast France [PDF]

open access: yes, 1992
Carbonate platforms are increasingly being studied using sequence stratigraphic concepts and models borrowed from the study of siliciclastic shelves in passive margin settings. The direct transposition of the stratigraphic model for a siliciclastic shelf
Hunt, David William
core  

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

open access: yesFEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens   +8 more
wiley   +1 more source

Clinical and Microbiological Characteristics of Klebsiella pneumoniae Bloodstream Infection in a Chinese Hospital: Hypervirulent and Multiclonal

open access: yesInfection and Drug Resistance, 2022
Zike Sheng,1,* Junjie Li,2,* Tingting Chen,3 Yan Zhu,4 Xueping Yu,5 Xiuhua He,5 Yijuan Zheng,5 Cuiping Ma,6 Minghui Zheng,5 Peiyun Wang,1 Ziqiang Li,1 Yumin Xu,7 Qing Xie,1 Zhijun Su,5 Sumei Chen5 1Department of Infectious Diseases, Ruijin ...
Sheng Z   +14 more
doaj  

Exploring Protein Sequence Space Using Computationally Directed Recombination [PDF]

open access: yes, 2006
Evolution has provided us with many protein sequences. However, these sequences represent a very small fraction of the possible sequences. In the laboratory, scientists have explored areas of sequence space not represented by natural proteins both to ...
Meyer, Michelle Margaret
core   +1 more source

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

open access: yesFEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

Antimicrobial Resistance of Hypervirulent Klebsiella pneumoniae: Epidemiology, Hypervirulence-Associated Determinants, and Resistance Mechanisms

open access: yesFrontiers in Cellular and Infection Microbiology, 2017
Klebsiella pneumoniae is one of the most clinically relevant species in immunocompromised individuals responsible for community-acquired and nosocomial infections, including pneumonias, urinary tract infections, bacteremias, and liver abscesses.
Chang-Ro Lee   +7 more
doaj   +1 more source

Sequence Types for Hereditary Permutators.

open access: yes, 2019
The invertible terms in Scott’s model D_infty are known as the hereditary permutators. Equivalently, they are terms which are invertible up to beta eta-conversion with respect to the composition of the lambda-terms. Finding a type-theoretic characterization to the set of hereditary permutators was problem # 20 of TLCA list of problems. In 2008, Tatsuta
openaire   +3 more sources

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