Results 141 to 150 of about 28,982 (257)
Comparing test sets and criteria in the presence of test hypotheses and fault domains
, 2002 A number of authors have considered the problem of comparing test sets and criteria. Ideally test sets are compared using a preorder with the property that test set T1 is at least as strong as T2 if whenever T2 determines that an implementation p is ...
Hierons, RM
core +1 more source
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
The Fibonacci Sequence and Schreier-Zeckendorf Sets
J. Integer Seq., 2019 A finite subset of the natural numbers is weak-Schreier if $\min S \ge |S|$, strong-Schreier if $\min S>|S|$, and maximal if $\min S = |S|$. Let $M_n$ be the number of weak-Schreier sets with $n$ being the largest element and $(F_n)_{n\geq -1}$ denote the Fibonacci sequence.
openaire +4 more sources
Integrated Sidelobe Level of sets of Rotated Legendre Sequences
, 2011 We here address the problem of constructing sets of sequences with low integrated aperiodic auto- and crosscorrelations when the constraint of antipodal symbols is enforced.
HABOBA, SALVADOR JAVIER +6 more
core +1 more source
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Formulaic Sequences: Importance to Academic English Writing
, 2019 Formulaic sequences are considered the building blocks of academic writing. Sound L2 teaching methodology indicates that to increase learners’ proficiency and performance in academic writing contexts they be taught formulaic sequences in the writing ...
Sage, Kristie +2 more
core
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source