Results 171 to 180 of about 1,430,679 (327)

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

EnDeep4mC predicts DNA <i>N</i> ⁴-methylcytosine sites using a dual-adaptive feature encoding framework in deep ensembles. [PDF]

Genome Res
Zhang S, Zou Q, Niu M, Lv Z, Stalin A, Luo X.   +5 more
europepmc   +1 more source

LACUNARY STATISTICAL SUMMABILITY OF SEQUENCES OF SETS

, 2015
Uğur Ulusu, Fatıh Nuray
openalex   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Automatic Selection of Search Parameter Values for Mass Spectrometry-Based Search Engines. [PDF]

J Proteome Res
Farag YM, Søgaard HØ, Barsnes H.
europepmc   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Protein Language Models: Applications and Perspectives. [PDF]

J Proteome Res
Leclercq M, Droit A.
europepmc   +1 more source

Primer binding region of the SSP set for Doryteuthis gahi in all available DNA sequences of the target species in FASTA format.

Alan Marín (5982971), Ruben Alfaro (5982992), Lorenzo E. Reyes-Flores (5982983), Claudia Ingar (21647796), Luis E. Santos-Rojas (21647799), Irina B. Alvarez-Jaque (21647802), Karen Rodríguez-Bernales (21647805), Cleila Carbajal (21647808), Angel Yon-Utrilla (21647811), Eliana Zelada-Mázmela (5982986)   +9 more
openalex   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Predicting Protein-Protein Interactions by Convolutional Neural Network Model. [PDF]

BioTech (Basel)
Shi S, Xiong T, Wang D, Wei L, Li L, Li Z, Lyu Y.   +6 more
europepmc   +1 more source