Results 261 to 270 of about 3,312,497 (352)

Rapid detection of G6PD deficiency SNPs using a novel amplicon-based minion sequencing assay. [PDF]

Sci Rep
Tacoli C, Kleinecke M, Hoon KS, Trimarsanto H, Nadeem M, Eam R, Khim N, Rumaseb A, Ley B, Sayre D, Phok S, Lek D, Witkowski B, Hwang J, Auburn S, Mueller I, Price RN, Popovici J.   +17 more
europepmc   +1 more source

“To Me, It Was Significant”: The Ethics of Returning Variants of Uncertain Significance from Clinical Exome Sequencing

, 2018
Kristin Clift, Colin Halverson, Jennifer B. McCormick   +2 more
openalex   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

SeqAfrica: empowering Africa's fight against antimicrobial resistance through genomics. [PDF]

Front Public Health
Nilsson P, Gibson CT, Thornval NR, Lacy-Roberts N, Odgaard C, Owusu-Nyantakyi C, Amuasi GR, Boateng W, Mohktar Q, Bortey A, Odih EE, Sunmonu GT, Kumburu HH, Sonda T, Bhiman JN, Amoako DG, du Plessis M, Adu B, van Zwetselaar M, von Gottberg A, Mmbaga BT, Okeke IN, Smith AM, Egyir B, Hendriksen RS.   +24 more
europepmc   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Heterogeneity of genetic sequence within quasi-species of influenza virus revealed by single-molecule sequencing. [PDF]

Elife
Tamao K, Noji H, Tabata K.
europepmc   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Comparative Evaluation of Sequencing Technologies for Detecting Antimicrobial Resistance in Bloodstream Infections. [PDF]

Antibiotics (Basel)
Papamentzelopoulou M, Vrioni G, Pitiriga V.   +2 more
europepmc   +1 more source

When the 3rd generation sequencing technologies go marching in

, 2017
Sachiko Isobe, Ryo Koyanagi, Ken Osaki
openalex   +2 more sources