Results 281 to 290 of about 3,312,497 (352)

Whole-genome sequencing identifies HOXD13 variants in syndactyly pedigrees. [PDF]

Hum Genomics
Xu YF, Zhang J, Wei TY, Zhang ML, Liu JE, Yang K, Tian YP, Hu HY.   +7 more
europepmc   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Molecular Characterization of a Complex <i>PDGFRB</i> Structural Variation in Infantile Myofibroma With Complete Response to Imatinib. [PDF]

JCO Precis Oncol
Bastianelli WE, Wu J, Ahsan MU, Szepessy AM, Schubert J, Balamuth NJ, Chan J, Denenberg EH, Luo M, Pollock AN, Russo PA, Rybacki K, Xu F, Zhong Y, Surrey LF, Wang K, Laetsch TW, Li MM.   +17 more
europepmc   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

SARS-CoV-2 wastewater genomic surveillance: approaches, challenges, and opportunities. [PDF]

Genome Biol
Munteanu V, Saldana MA, Dreifuss D, Ouyang WO, Ferdous J, Mohebbi F, Roseberry JS, Ciorba D, Bostan V, Gordeev V, Drabcinski N, Su JM, Kasianchuk N, Sharma NK, Knyazev S, Aßmann E, Lobiuc A, Covasa M, Crandall KA, Wu NC, Mason CE, Tierney BT, Lucaci AG, Ophoff RA, Gibas C, Rzymski P, Skums P, Solo-Gabriele H, Niko B, Zelikovsky A, Hölzer M, Smith A, Mangul S.   +32 more
europepmc   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Assessing the Detection Power of Genome-Wide Copy Number Variation Profiles in Prostate Cancer Using Simulated Shallow Whole-Genome Sequencing Data. [PDF]

JCO Clin Cancer Inform
Pamidimarri Naga S, Slootbeek PHJ, Tolmeijer SH, Gillissen C, Ligtenberg MJL, Mehra N, de Voer RM.   +6 more
europepmc   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Protocol for the identification of selected genes and haplotype analysis in soybean using next-generation sequencing. [PDF]

STAR Protoc
Zhu Z, Tian Z.
europepmc   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source