Results 141 to 150 of about 28,623 (311)

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Impact of bed roughness and submergence on velocity profiles and flow structures in hydraulic jumps. [PDF]

Sci Rep
Agrawal N, Padhi E, Larrarte F, Singhal GD.   +3 more
europepmc   +1 more source

Enhancing Reservoir Design by Integrating Resilience into the Modified Sequent Peak Algorithm (MSPA 2024) [PDF]

Issa Saket Oskoui, María Manuela Portela, Carina Almeida   +2 more
openalex   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Paclitaxel Drug-Coated Balloon Angioplasty for Medically Refractory Intracranial Atherosclerotic Disease: A US Single-Center Experience With the AGENT Balloon. [PDF]

Stroke Vasc Interv Neurol
Chaudhari A, Rosenstein ZM, Kamal R, Khan N, Almajali M, Ramirez-Abreu D, Al-Ghetaa JK, Ashouri Y, Lin E, Zaidat OO.   +9 more
europepmc   +1 more source

Herbrand Sequent Extraction [PDF]

, 2008
Stefan Hetzl, Alexander Leitsch, Daniel Weller 0001, Bruno Woltzenlogel Paleo   +3 more
openaire   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Correction: Gao et al. <i>Camellia japonica</i> Flower Extract and the Active Constituent Hyperoside Repair DNA Damage Through FUNDC1-Mediated Mitophagy Pathway for Skin Anti-Aging. <i>Antioxidants</i> 2025, <i>14</i>, 968. [PDF]

Antioxidants (Basel)
Gao H, Shi J, Li G, Lai Z, Liu Y, Yuan C, Mei W.   +6 more
europepmc   +1 more source

On the relationship between hypersequent calculi and labelled sequent calculi for intermediate logics with geometric Kripke semantics

, 2010
Robert Rothenberg
openalex   +1 more source

Refining the Search: Implementing and Optimising a Backwards Proof Search in LK' Sequent Calculus

Daniel Busing
openalex   +1 more source