Results 101 to 110 of about 5,524 (273)
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
On Affine Logic and {\L}ukasiewicz Logic [PDF]
, 2014 The multi-valued logic of {\L}ukasiewicz is a substructural logic that has been widely studied and has many interesting properties. It is classical, in the sense that it admits the axiom schema of double negation, [DNE]. However, our understanding of {\L}
Arthan, Rob, Oliva, Paulo
core
Sequent calculi for three-valued logics
Tsukuba Journal of Mathematics, 1998 This paper presents complete sequent calculi for different 3-valued propositional logics, in a uniform way. Each calculus is built around the structural rules: thinning, contraction, interchange and cut, using so-called beginning sequents and logical rules of inference which are specific for that logic.
openaire +2 more sources
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Neutrality and Many-Valued Logics [PDF]
, 2007 In this book, we consider various many-valued logics: standard, linear, hyperbolic, parabolic, non-Archimedean, p-adic, interval, neutrosophic, etc. We survey also results which show the tree different proof-theoretic frameworks for many-valued logics, e.
Schumann, Andrew, Smarandache, Florentin
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Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Sequent calculi and decidability for intuitionistic hybrid logic
Information and Computation, 2011 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Galmiche, Didier, Salhi, Yakoub
openaire +3 more sources
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source