Results 51 to 60 of about 715 (255)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Gentzen and Temporal Sequents

Studies in Logic, Grammar and Rhetoric
The paper presents a comparison of two generalised sequent calculi for temporal logics. In both cases the main technical solution is the multiplication of the sorts of sequents and, additionally, the application of some kind of labelling to formulae. The
Indrzejczak Andrzej
doaj   +1 more source

Converting ALC Connection Proofs into ALC Sequents [PDF]

Electronic Proceedings in Theoretical Computer Science, 2019
The connection method has earned good reputation in the area of automated theorem proving, due to its simplicity, efficiency and rational use of memory. This method has been applied recently in automatic provers that reason over ontologies written in the
Eunice Palmeira, Fred Freitas, Jens Otten   +2 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Grouping based calculus for propositional linear temporal logic

Lietuvos Matematikos Rinkinys
In this paper, the authors research the problem of loops in linear temporal logic PLTL. The task involves defining the standard rule application process for the derivation procedure (as used in [4] and [5]), determining and proving properties for the ...
Kostas Ragauskas, Adomas Birštunas
doaj   +3 more sources

Loop-check free sequent calculi for unary fragment of temporal logic

Lietuvos Matematikos Rinkinys
This paper explores the construction of an efficient sequent calculus for a selected fragment of porpositional linear temporal logic (PLTL), extending the ideas of classical calculi discussed in [1], and builds upon previous investigations into the ...
Lukas Maksimiak, Adomas Birštunas
doaj   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Internal and External Calculi: Ordering the Jungle without Being Lost in Translations

Bulletin of the Section of Logic
This paper gives a broad account of the various sequent-based proof formalisms in the proof-theoretic literature. We consider formalisms for various modal and tense logics, intuitionistic logic, conditional logics, and bunched logics. After providing an
Tim S. Lyon, Agata Ciabattoni, Didier Galmiche, Marianna Girlando, Dominique Larchey-Wendling, Daniel Méry, Nicola Olivetti, Revantha Ramanayake   +7 more
doaj   +1 more source