Results 61 to 70 of about 715 (255)
FEBS Letters, EarlyView.Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai +4 more
wiley +1 more source
Permutability of proofs in intuitionistic sequent calculi
Theoretical Computer Science, 1999 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Roy Dyckhoff, Luís Pinto 0001
openaire +3 more sources
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Uniform interpolation and the existence of sequent calculi
Annals of Pure and Applied Logic, 2019 A propositional logic \(L\) has \textit{uniform interpolation} if for every formula \(\phi\) and variable \(p\), there are formulas \(\forall p\,\phi\) and \(\exists p\,\phi\) not containing \(p\) such that \begin{align*} \vdash_L\psi\to\phi&\iff\vdash_L\psi\to\forall p\,\phi,\\ \vdash_L\phi\to\psi&\iff\vdash_L\exists p\,\phi\to\psi \end{align*} for ...
openaire +5 more sources
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
Sequent and hypersequent calculi for abelian and łukasiewicz logics
ACM Transactions on Computational Logic, 2005 We present two embeddings of Łukasiewicz logicŁinto Meyer and Slaney's Abelian logicA, the logic of lattice-ordered Abelian groups. We give new analytic proof systems forAand use the embeddings to derive corresponding systems forŁ. These include hypersequent calculi, terminating hypersequent calculi, co-NP labeled sequent calculi, and unlabeled sequent
G., Metcalfe +2 more
openaire +3 more sources
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
Sequent calculi and decidability for intuitionistic hybrid logic
Information and Computation, 2011 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Galmiche, Didier, Salhi, Yakoub
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Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Ergo, An Open Access Journal of PhilosophyLogical inferentialism is the view that the meaning of logical constants is implicitly defined by the operational rules that govern their behaviour in proofs—particularly in sequent calculus proofs, according to an increasingly dominant tendency.
Bogdan Dicher, Francesco Paoli
doaj +2 more sources