Results 101 to 110 of about 14,982 (276)
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Labeled Sequent Calculus for Orthologic
Bulletin of the Section of Logic, 2018 Orthologic (OL) is non-classical logic and has been studied as a part of quantumlogic. OL is based on an ortholattice and is also called minimal quantum logic. Sequent calculus is used as a tool for proof in logic and has been examinedfor several decades.
openaire +5 more sources
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
A Sequent Calculus for Urn Logic [PDF]
Journal of Logic, Language and Information, 2015 Approximately speaking, an urn model for first-order logic is a model where the domain of quantification changes depending on the values of variables which have been bound by quantifiers previously. In this paper we introduce a model-changing semantics for urn-models, and then give a sequent calculus for urn logic by introducing formulas which can be ...
openaire +2 more sources
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Ordinal analysis and the set existence property for intuitionistic set theories. [PDF]
Philos Trans A Math Phys Eng Sci, 2023 Rathjen M.
europepmc +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Loop-free sequent calculus for modal logic K4
Lietuvos Matematikos Rinkinys, 2009 In the article, a loop-free calculus for modal logic K4 is presented. The calculus is based on marks and indices method which was first used for logic S4.
Julius Andirkonis
doaj +1 more source
Cut Elimination inside a Deep Inference System for Classical Predicate Logic [PDF]
, 2018 Deep inference is a natural generalisation of the one-sided sequent calculus where rules are allowed to apply deeply inside formulas, much like rewrite rules in term rewriting.
Brünnler, Kai
core
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source