Results 91 to 100 of about 2,868 (293)

Tools and techniques for formalising structural proof theory

open access: yes, 2010
Whilst results from Structural Proof Theory can be couched in many formalisms, it is the sequent calculus which is the most amenable of the formalisms to metamathematical treatment.
Chapman, Peter
core  

2-sequent calculus: intuitionism and natural deduction

open access: yes, 1993
This approach to studying the minimal intuitionistic modal logic is based on a generalization of Gentzen's original sequent calculus introduced and developed by the author in a previous paper [see Ann. Pure Appl. Logic 58 (1992), no.
MASINI, Andrea
core   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

open access: yesMolecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel   +6 more
wiley   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

open access: yesMolecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos   +6 more
wiley   +1 more source

Elimination of loop-check for logic of idealized knowledge

open access: yesLietuvos Matematikos Rinkinys, 2009
In the paper loop-check-free sequent calculus for logic of idealized knowledge is presented. To obtain termination of derivation indices and marks are used instead of history.
Aida Pliuškevičienė
doaj   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

A Labelled Sequent Calculus for BBI: Proof Theory and Proof Search

open access: yes, 2013
We present a labelled sequent calculus for Boolean BI (BBI), a classical variant of the logic of Bunched Implication. The calculus is simple, sound, complete, and enjoys cut-elimination.
Goré, Rajeev   +5 more
core   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

A Classical Sequent Calculus with Dependent Types [PDF]

open access: yesACM Transactions on Programming Languages and Systems, 2017
Dependent types are a key feature of the proof assistants based on the Curry-Howard isomorphism. It is well known that this correspondence can be extended to classical logic by enriching the language of proofs with control operators. However, they are known to misbehave in the presence of dependent types, unless dependencies are restricted to values ...
openaire   +5 more sources

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