Results 71 to 80 of about 136,655 (280)
A labelled sequent calculus for BBI: proof theory and proof search
, 2018 We present a labelled sequent calculus for Boolean bunched implications (BBI), a classical variant of the logic of Bunched Implications (BI). The calculus is simple, sound, complete and enjoys cut-elimination. We show that all the structural rules in the
Goré, Rajeev, Tiu, Alwen, Hou, Zhe
core +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
A Systematic Approach to Canonicity in the Classical Sequent Calculus [PDF]
, 2012 International audienceThe sequent calculus is often criticized for requiring proofs to contain large amounts of low-level syntactic details that can obscure the essence of a given proof.
Hetzl, Stefan +2 more
core +1 more source
Interaction and Depth against Nondeterminism in Proof Search [PDF]
Logical Methods in Computer Science, 2014 Deep inference is a proof theoretic methodology that generalizes the standard notion of inference of the sequent calculus, whereby inference rules become applicable at any depth inside logical expressions.
Ozan Kahramanogullari
doaj +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Loop-check free sequent calculi for unary fragment of temporal logic
Lietuvos Matematikos RinkinysThis paper explores the construction of an efficient sequent calculus for a selected fragment of porpositional linear temporal logic (PLTL), extending the ideas of classical calculi discussed in [1], and builds upon previous investigations into the ...
Lukas Maksimiak, Adomas Birštunas
doaj +1 more source
The G4i Analogue of a G3i Sequent Calculus
Studia Logica, 2022 AbstractThis paper provides a method to obtain terminating analytic calculi for a large class of intuitionistic modal logics. For a given logic with a cut-free calculus that is an extension of the method produces a terminating analytic calculus that is an extension of and equivalent to .
openaire +3 more sources
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source