Results 131 to 140 of about 17,798 (304)

Numerical and experimental investigation of process parameters optimization in hammer forging for minimizing risk of crack

Journal of Advanced Mechanical Design, Systems, and Manufacturing
Hammer forging is a traditional manufacturing technology to produce high stiffness product and is widely used in heavy industries. In the hammer forging, the product is produced through several blows. Unlike forging using mechanical press, the product is
Satoshi KITAYAMA, Reo SUGITA, Shuhei KONDO, Koji MIYOSHI, Eri AONO, Masaharu AMANO   +5 more
doaj   +1 more source

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

FEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo, Keisuke Okuno, Shuichi Watanabe, Sakiko Oba, Hiroyasu Kagawa, Masanori Tokunaga, Daisuke Ban, Yusuke Kinugasa   +7 more
wiley   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

On alternative solution methods for solving approximate subproblems in SAO (Sequential Approximate Optimization)

, 2015
Thesis (MSc)--Stellenbosch University, 2015.ENGLISH ABSTRACT: In this study, we focus our attention on sequential approximate optimization (SAO) techniques for large scale nonlinear constrained simulation based optimization problems, and aim to add to ...
Cronje, Marlize
core  

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Gradient-based approximate design optimization

, 2005
The research presented in this thesis deals with gradient-enhanced approximate design optimization. This research has been carried out as part of the ADOPT project (Approximate Design OPTimization), a joint STW project with the Eindhoven University of ...
Vervenne, K. (author), Vervenne, K.
core  

Sequential Decision Making For Choice Functions On Gambles [PDF]

, 2011
Choice functions on gambles (uncertain rewards) provide a framework for studying diverse preference and uncertainty models. For single decisions, applying a choice function is straightforward.
HUNTLEY, NATHAN
core  

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Improved Monthly Runoff Prediction of OSELM Based on Secondary Decomposition Technique and Optimization of Ten "Bird" Swarm Algorithms

Renmin Zhujiang
To improve the accuracy of monthly runoff time series prediction and enhance the performance of online sequential extreme learning machine (OSELM) prediction, ten "bird" swarm algorithms were compared and validated for optimization, including satin ...
DENG Zhiyu, CUI Dongwen
doaj   +2 more sources

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source