Results 181 to 190 of about 825,885 (311)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Detection of Trends of Internet Traffic Using Sequential Patterns

We propose a new method of possible trend detection in the internet traffic by using sequential pattern analysis. The main steps of this method, such as the template pattern discovery in time-series data and pattern comparison and matching for sequential
Lauks, Gunārs, Jeļinskis, Jans
core  

Sequential nonlinear manifold learning

, 2007
The computation of compact and meaningful representations of high dimensional sensor data has recently been addressed through the development of Nonlinear Dimensional Reduction (NLDR) algorithms.
Upcroft, H. F., Upcroft, B., Durrant-Whyte, H. F., Guivant, J., Kumar, S., Guivant, B.   +5 more
core  

Legendre polynomial transformation and energy-weighted random forests for sequential data classification. [PDF]

Sci Rep
Olaniran OR, Alghamdi FM, Alharbi NM, Abd-Elmougod GA, Alzubaidi S, Muse AH.   +5 more
europepmc   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

InfoMat: Leveraging Information Theory to Visualize and Understand Sequential Data. [PDF]

Entropy (Basel)
Tsur D, Permuter H.
europepmc   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Automated Risk Prediction of Post-Stroke Adverse Mental Outcomes Using Deep Learning Methods and Sequential Data. [PDF]

Bioengineering (Basel)
Oei CW, Ng EYK, Ng MHS, Chan YM, Subbhuraam V, Chan LG, Acharya UR.   +6 more
europepmc   +1 more source

Machine Learning on Sequential Data Using a Recurrent Weighted Average. [PDF]

Neurocomputing (Amst), 2019
Ostmeyer J, Cowell L.
europepmc   +1 more source