Results 81 to 90 of about 187,316 (264)

Neural network algorithm based on reinforcement learning for vectorization of aerial and space images [PDF]

The International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences
This paper presents a novel reinforcement learning (RL) framework for automated vectorization of high-resolution aerial imagery, addressing key challenges in geospatial analysis through adaptive feature extraction and sequential decision-making.
A. Emelyanov, A. Emelyanov, V. Knyaz, V. Knyaz, V. Kniaz, V. Kniaz   +5 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

RETRACTED: Stopping peculiarities of the iterative algorithm for identifying scenes in at video stream [PDF]

BIO Web of Conferences
This article has been retracted because it substantially reflects the content and analysis of the following original published article without reference to it: K. Bulatov, N. Razumnyi, V.V. Arlazarov.
Alexandrov Islam, Titova Anastasia, Nogmov Muhamed, Karpov Nikita   +3 more
doaj   +1 more source

A SEQUENTIAL LEARNING ANALYSIS OF DECISIONS IN ORGANIZATIONS TO ESCALATE INVESTMENTS DESPITE CONTINUING COSTS OR LOSSES [PDF]

Journal of Applied Behavior Analysis, 1992
Reinforcement processes may underlie decisions frequently found in organizations to escalate investments of time, money, and other resources in strategies (e.g., product development, capital investment, plant expansion) that do not result in immediate reinforcers.
openaire   +2 more sources

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

An evaluation of the replicability of analyses using synthetic health data

Scientific Reports
Synthetic data generation is being increasingly used as a privacy preserving approach for sharing health data. In addition to protecting privacy, it is important to ensure that generated data has high utility.
Khaled El Emam, Lucy Mosquera, Xi Fang, Alaa El-Hussuna   +3 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source