Results 241 to 250 of about 531,743 (299)

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

FEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo, Keisuke Okuno, Shuichi Watanabe, Sakiko Oba, Hiroyasu Kagawa, Masanori Tokunaga, Daisuke Ban, Yusuke Kinugasa   +7 more
wiley   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Extraction of Sequential Patterns Using PREFIXSPAN

International Journal of Computer Sciences and Engineering
Elliot S.J., Bennett E.O.
openaire   +1 more source

Sequential extraction for Palaeo-proterozoic BIF and implications

, 2015
Oonk, Paul B.H., Tsikos, Harilaos, Mason, Paul, Staubwasser, Michael, Henkel, Susann, Williams, Helen M.   +5 more
openaire   +2 more sources

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Sequential Extraction of Minor Components

Neural Processing Letters, 2001
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Chen, Tianping, Amari, Shun-Ichi, Murata, Noboru   +2 more
openaire   +2 more sources

Pitfalls of sequential extractions

Water Research, 1990
Abstract An increasing number of researchers are using sequential extractions to determine the speciation of trace elements in sediments. Unfortunately, sequential extraction methods have not been successfully validated. The results are simply taken as providing “operational definitions” of the phases one is trying to measure.
P.M.V. Nirel, F.M.M. Morel
openaire   +1 more source

Minerva: Sequential Covering for Rule Extraction

IEEE Transactions on Systems, Man, and Cybernetics, Part B (Cybernetics), 2008
Various benchmarking studies have shown that artificial neural networks and support vector machines often have superior performance when compared to more traditional machine learning techniques. The main resistance against these newer techniques is based on their lack of interpretability: it is difficult for the human analyst to understand the ...
Huysmans, Johan, Setiono, Rudy, Baesens, Bart, Vanthienen, Jan   +3 more
openaire   +3 more sources