Results 171 to 180 of about 310,714 (306)
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
BicSPAM: flexible biclustering using sequential patterns. [PDF]
BMC Bioinformatics, 2014 Henriques R, Madeira SC.
europepmc +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Chspm: a complete hybrid sequential patterns mining algorithm
, 2010 碩士現有循序樣式探勘的研究依照樣式中相連的項目是否必須在交易紀錄中緊密相連可粗略的分為以下三類，第一類為找出連續循序樣式；第二類為找出非連續循序樣式；第三類為找出混合循序樣式。過去混合循序樣式探勘的演算法都以Apriori為基礎，但這些方法探勘出的結果並不完整，所以我們針對混合循序樣式探勘，以樣式成長(pattern-growth)方法為基礎，提出一個新的演算法CHSPM(A Complete Hybrid Sequential Patterns Mining Algorithm ...
原孝任; Yuan, Hsiau-ren
core
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Visualizing Sequential Patterns for Text Mining
, 2000 A sequential pattern in data mining is a finite series of elements such as A B C D where A, B, C, and D are elements of the same domain. The mining of sequential patterns is designed to find patterns of discrete events that frequently happen in the ...
Wendy Cowley +4 more
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Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
TSP: Mining Top-K Closed Sequential Patterns
, 2003 Sequential pattern mining has been studied extensively in data mining community. Most previous studies require the specification of a minimum support threshold to perform the mining.
Xifeng Yan, Petre Tzvetkov, Jiawei Han
core