Results 121 to 130 of about 268,793 (310)
Molecular Oncology, EarlyView.Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy +10 more
wiley +1 more source
Education SciencesThe current study aimed to explore the incidence and severity of the mental health difficulties of ethnically diverse students at University of London institutions.
Jessica D. Jones Nielsen +2 more
doaj +1 more source
, 2019 La multiplicación masiva de bacterias promotoras de crecimiento vegetal es un aspecto fundamental para la producción de bioinoculantes. Con el objetivo de evaluar una estrategia experimental que permitiera identificar factores nutricionales con influencia sobre la multiplicación de Azotobacter chroococcum AC1, se realizó la aplicación secuencial de ...
Moreno Galván, Andrés Eduardo +2 more
openaire +1 more source
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
Adaptive sequential sampling for extreme event statistics in ship design
, 2018 For more than a century, many facets of ship design have fallen into the domain of rules-based engineering. Recent technological progress has been validated to the point that many of these areas will soon warrant reconsideration. In this emerging environment, accurately predicting the motions and loading conditions which a ship is likely to encounter ...
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Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Philippine Social Science JournalEmploying an explanatory sequential mixed-method design, this study assesses entrepreneurial competencies and succession planning among family business owners in a second-class Filipino municipality.
Elaine B. Sobrevega, Grace L. Lopena
doaj +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source