Results 171 to 180 of about 517,052 (312)

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Functional cure in an occult hepatitis B virus infection patient on sequential therapy: A case report. [PDF]

World J Hepatol
Wang L, Liang H, Wang C, Liang MY, Zeng QL, Zhu PF, Lv J.   +6 more
europepmc   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Corticosteroid-to-sirolimus sequential therapy: a case series of infantile kaposiform hemangioendothelioma associated with Kasabach-Merritt phenomenon. [PDF]

Transl Pediatr
Tan X, Liu Z, Chen K, Zhang M, Xia J, Niu C, Li H.   +6 more
europepmc   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Novel Sequential Therapy with Obinutuzumab and Telitacicept in Severe Lupus Nephritis with Glucocorticoid-Induced Avascular Necrosis (AVN) of the Femoral Head: A Case Report. [PDF]

Am J Case Rep
Zhang Y, Huang L, Li N, Zeng X, Zheng Z, Wang X, Zhang Y, Tang C.   +7 more
europepmc   +1 more source

Efficacy of Sequential Therapy as the First-Line Treatment in the Eradication of Helicobacter pylori. [PDF]

Cureus, 2023
Tamene Y, Mody SP, Sadiq KO, Shivakumar YM, Burra E, Shahid K, Nath TS.   +6 more
europepmc   +1 more source

Incidence of fistulas following human pancreas transplantation [PDF]

, 1987
Abendroth, D., Gottwald, T., Illner, Wolf-Dieter, Land, Walter   +3 more
core   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Efgartigimod Followed by Telitacicept in Adult Generalized Myasthenia Gravis: A Retrospective Case Series

Journal of Inflammation Research
Yuan Zhang,1,* Zheyu Fang,1,* Yaping Liu,2,* Bingbing Wan,1 Qiaoyi Zhang,1 Xi Qu,1 Shengli Pan,1 Yu Zhang,1 Yilin Dai,1 Shiyin Yang,1 Jia Li,1 Xu Zhang1 1Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University ...
Zhang Y, Fang Z, Liu Y, Wan B, Zhang Q, Qu X, Pan S, Zhang Y, Dai Y, Yang S, Li J, Zhang X   +11 more
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