Results 51 to 60 of about 2,148 (195)
A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma
FEBS Letters, EarlyView.Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos +9 more
wiley +1 more source
“Non sanza prima far grande aggirata” – Turning the Pages in Dante and Botticelli
Dante e l'Arte, 2014 The paper analyses the sequentiality of Dante’s narrative in Inferno VIII–XI, and its pictorial translation by Sandro Botticelli. It intends to show the major intermedial differences of expression and their theological consequences.
Sven Thorsten Kilian
doaj +1 more source
Metastatic niche shaped by host factors influences disseminated cancer cell fate
FEBS Letters, EarlyView.Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward +2 more
wiley +1 more source
FEBS Letters, EarlyView.Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana +3 more
wiley +1 more source
Margin-Based Deep Learning Networks for Human Activity Recognition
Sensors, 2020 Human activity recognition (HAR) is a popular and challenging research topic, driven by a variety of applications. More recently, with significant progress in the development of deep learning networks for classification tasks, many researchers have made ...
Tianqi Lv +4 more
doaj +1 more source
What is the right notion of sequentiality?
, 2010 In this paper we give an informally semi-rigorous explanation of the notion of sequentiality. We argue that the classical definition, due to Pudlak, is slightly too narrow.
Visser, Albert
core
Documentscape: Intertextuality, Sequentiality & Autonomy at Work
, 2014 On the basis of an ethnographic field study, this article introduces the concept of documentscape to the analysis of document-centric work practices. The concept of documentscape refers to the entire ensemble of documents in their mutual intertextual ...
Pernille Bjorn +3 more
core +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Forum: Qualitative Social Research, 2008 The paper aims at demonstrating some analytical potentialities of video data for the study of social interaction. It is based on video recordings of situated activities in their ordinary settings—producing "naturally occurring data" within a naturalistic
Lorenza Mondada
doaj
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source