Results 161 to 170 of about 2,962,676 (306)

Single‐Cell RNA Editing Identifies T Cell ADAR1 as a Key Regulator of Immune Exhaustion and Anti‐PD‐1 Resistance in Colorectal Cancer

Advanced Science, EarlyView.
Single‐cell RNA editing analysis identifies ADAR1 as a regulator of dysfunctional T cell states in colorectal cancer. Elevated ADAR1 activity promotes T cell exhaustion and impairs antitumor immunity partly through TGF‐β‐SMAD signaling, contributing to anti‐PD‐1 resistance and highlighting T cell ADAR1 as a potential therapeutic target and biomarker ...
Da Kang, Song‐Zuo Xie, Yong‐Zhou Luo, Xin‐Pei Deng, Xi‐Rong Tan, Ze‐Geng Chen, Ling‐Xing Zeng, Gong Chen, Pei‐Rong Ding, Zhi‐Zhong Pan, Rong‐Xin Zhang   +10 more
wiley   +1 more source

Astenosfera: ser o no ser

, 2013
Este artículo contiene una revisión de la historia y contenido actual de un concepto, el de astenosfera, clave en las modernas Ciencias de la Tierra. Definido por Barrell en 1914, cuando Wegener diseñaba su primer ataque a la Tierra inmóvil, fue rescatado por los geofísicos revolucionarios de la década de 1960 sólo para ser secuestrado a continuación ...
Fernández, Carlos, Alonso Chaves, Francisco M., Anguita Virella, Francisco   +2 more
openaire   +2 more sources

II Encuentro musical

, 1986
II Encuentro musical (4,5 i 6 de juliol de 1986) enregistrat per Cadena Ser des de les platges de Benicàssim. Recull la connexió amb la Creu Roja i les entrevistes a Enrique de Pablo, gerent del Patronat de Turisme de Castelló, Eduardo Rodríguez i ...
Radio Castellón Cadena SER
core  

Tandem Duplication‐Driven Neofunctionalization of UDP‐Glycosyltransferases Shapes the Diversification of Triterpenoid Saponins in the Cucurbitaceae

Advanced Science, EarlyView.
We present a chromosome‐level genome assembly of Siraitia grosvenorii and, through comparative genomics, uncover a conserved UGT73 tandem array driving triterpenoid saponin diversification in Cucurbitaceae. Crystalized SgUGT73AM30 further reveals the regioselectivity mechanism underlying its catalytic activity.
Guangyi Wang, Mengmeng Li, Xuehui Dai, Yanchen Zhang, Yuhan Wu, Zhaotao Yan, Chenfei Tian, Hongkai Fan, Haili Liu, Xiaowei Zhang, Yiming Yang, Jiayu Lu, Yuwei Sun, Yong Wang   +13 more
wiley   +1 more source

Age Modifies the Comparative Effectiveness of DIMS Versus HAL Spectacle Lenses for Myopia Control: A Real-World Study. [PDF]

Transl Vis Sci Technol
Chen L, Sun L, Liu J, Chen Y, Li J, Lin D, Chen X, Leung HY, Zhang J, Lam DSC.   +9 more
europepmc   +1 more source

Functional Suppression of SCAP Triggers Endoplasmic Reticulum Stress‐Dependent Ferroptosis by Impairing Cholesterol Metabolism in Gastric Cancer

Advanced Science, EarlyView.
This study reveals a novel GC therapy targeting cholesterol homeostasis. Inhibiting the SCAP sterol‐sensing domain causes lethal ER stress via cholesterol accumulation, paradoxically forcing continuous synthesis that triggers ferroptosis. The findings link sterol sensing, metabolic dysregulation, and ferroptosis, establishing an anti‐cancer paradigm ...
Qianqian Xu, Guangzhao Pan, Lele Zhang, Xiangliu Chen, Kui Zhang, Yang Lu, Zibo Duan, Aiping Chen, Hailong Shen, Yuxi Zhang, Xiaowu Dong, Jinzhou Huang, Xing Huang, Kai Miao, Qian Hua, Fangfang Tao, Weidong Zhang, Jiang‐Jiang Qin   +17 more
wiley   +1 more source

Environmental enrichment is associated with enhanced novel object recognition performance and an increased proportion of smooth endoplasmic reticulum-containing spines in the dentate gyrus of Septin3^-/- mice. [PDF]

Mol Brain
Ageta-Ishihara N, Fuse N, Suzuki A, Fukazawa Y, Kinoshita M.   +4 more
europepmc   +1 more source

Femtosecond‐Laser Nanocavitation Regenerates SERS‐Active Plasmonic Nanogaps for Longitudinal Molecular Sensing at Biointerfaces

Advanced Science, EarlyView.
A regenerative molecular sensing platform that co‐localizes surface‐enhanced Raman spectroscopy (SERS) sensing and nanocavitation‐based actuation. Femtosecond‐laser triggered nanocavitation produces thermomechanical forces to locally regenerate SERS‐active nanogaps in protein‐rich biofluids while preserving optical performance.
Aditya Garg, Ze Zong, Meitong Nie, Stacie E. Deaver, Elizabeth M. Van Order, Elieser Mejia, Peter Vikesland, Erin S. Gloag, Wei Zhou   +8 more
wiley   +1 more source

Phylogeny and taxonomy of <i>Iris</i> (Iridaceae) series <i>Tenuifoliae</i>: Discovery of a clade with chloroplast genome inversion and description of three new species. [PDF]

PhytoKeys
Zhang Z, Li H, Zhang G, Zuo T.
europepmc   +1 more source

Programa - SER PILO PAGA

, 2017
Programa - SER PILO PAGA: Relato de la experiencia positiva de varios estudiantes de la Universidad de Medellín beneficiarios del programa Ser Pilo Paga.
Facultad de Ciencias Económicas y Administrativas, Facultad de Ingenierías, Facultad de Diseño, Facultad de Derecho, Facultad de Comunicación, Facultad de Ciencias Básicas, Facultad de Ciencias Sociales y Humanas   +6 more
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