Results 201 to 210 of about 600,641 (257)

Isosteric Engineering of Enzymes: Overcoming Activity–Stability Trade‐Offs by Site‐Selective CH → N Substitutions

Angewandte Chemie, EarlyView.
Coupling biosynthetic noncanonical amino acid production with genetic code expansion enables site‐specific incorporation of azatryptophans into PET‐degrading enzymes (PETases). By isosteric single‐atom editing of a conserved tryptophan, AzaPETases break the activity–stability trade‐off, delivering higher catalytic efficiency at elevated temperature and
Elwy H. Abdelkader, Haocheng Qianzhu, Gottfried Otting, Thomas Huber   +3 more
wiley   +1 more source

Progranulin deficiency in the brain activates an insulin signaling pathway that may promote neurodegeneration. [PDF]

iScience
Sajan MP, Aggarwal G, Hwang JJ, Smith DM, Cooper DR, Duncan MA, Hansen BC, Nguyen AD, Farese RV.   +8 more
europepmc   +1 more source

Biosynthesis of the Fully Saturated C16 Homosesquiterpene Descartane Through Deprotonation With Cyclopropanation

Angewandte Chemie International Edition, EarlyView.
A non‐canonical C16 sesquiterpene synthase from Morganella morganii produces the unusual scaffold descartane. Its cyclisation mechanism was rationalised by isotopic labelling experiments and DFT calculations. Site‐directed mutagenesis altered enzyme function, resulting in alternative products, including voltairene, which requires a different ...
Kexin Yang, Philip Troycke, Bernd Goldfuss, Michael Groll, Jeroen S. Dickschat   +4 more
wiley   +1 more source

Blood levels of D-aspartate oxidase, D-amino acid oxidase, serine racemase, and pLG72 are influenced by diagnoses of schizophrenia and autism spectrum disorder. [PDF]

Schizophrenia (Heidelb)
Maffioli E, Errico F, Motta Z, di Vito R, Grana J, De Grandis E, Boeri S, Bruno C, Riccio MP, Iasevoli F, Di Maio M, Nuzzo T, Bravaccio C, Bagnasco S, Gelzo M, Castaldo G, de Bartolomeis A, Negri A, Pollegioni L, Tedeschi G, Usiello A.   +20 more
europepmc   +1 more source

Ser investigador, ser editor, ser autor

, 2005
openaire   +1 more source

Verdade e liberdade: ser, dever-ser e poder-ser [PDF]

, 2015
openaire   +1 more source

Combining visual acuity with refraction reduces overestimation of myopia prevalence in school screenings: an age-stratified analysis. [PDF]

Front Med (Lausanne)
Li N, Jiang Y, Zhang X, Huang W, Zhang J, Zhang B, Gao Z, Leng Y.   +7 more
europepmc   +1 more source

Modo de dormir e relação mãe-criança

Psicologia: Ciência e Profissão
Elaine Pedreira Rabinovich
doaj   +1 more source

Management of myopia: a mini-review. [PDF]

Med Hypothesis Discov Innov Ophthalmol
Grzybowski A, Lanca C.
europepmc   +1 more source

Position Statement on Multimodal Cardiac Imaging in Patients with Systemic Diseases - 2026. [PDF]

Arq Bras Cardiol
Hotta VT, Costa IBSDS, Felix RCM, Bosco MEO, Romano MMD, Santorio NC, Brandão SCS, Frota DDCR, Lianza AC, Santos SND, Melo MDT, Rodrigues ACT, Fialho GL, Sawamura KSS, Alves MSL, Mattoso AAA, Mesquita CT, Mancuso FJN, Garcia MI, Pena JLB, Beck ALS, Soares AM, Silva SME, Torreão JA, Schvartzman PR, Fernandes F, Rochitte CE, Barberato SH.   +27 more
europepmc   +1 more source