Results 131 to 140 of about 3,459,447 (272)

Indole‐3‐Propionic Acid Improves Alveolar Development Impairment via Targeting VAMP8‐mediated SNAREs Complex Formation in Bronchopulmonary Dysplasia

Advanced Science, EarlyView.
This study aims to evaluate the impact of the tryptophan‐derived metabolite indole‐3‐propionic acid (IPA) on lung development and autophagic flux. IPA alleviates hyperoxia‐induced alveolar arrest by promoting autophagosome‐lysosome fusion via inhibition of VAMP8 phosphorylation, which is suggestive of a promising therapeutic target of BPD.
Beibei Wang, Xu Chen, Haowei Xu, Zhiqi Zeng, Keyu Lu, Yu Mao, Qianru Lv, Hui Shi, Song Liu, Xian Shen, Chunyu Yin, Yang Yang, Yan Guo, Xingyun Wang, Rui Cheng   +14 more
wiley   +1 more source

A proteção da qualidade de vida por meio do direito sanitário e do direito do ambiente

Cadernos Ibero-Americanos de Direito Sanitário, 2017
A defesa do direito fundamental à saúde e do direito fundamental ao ambiente sadio e equilibrado estão associados, uma vez que o ser humano, inserido no contexto ecológico, depende de um ambiente sadio para ter saúde e qualidade de vida, sendo o Direito
Roberta Fernande de Faria
doaj  

Engineering substrates for SERS : fundamentals and applications

, 2008
This work describes studies on sphere segment void (SSV) substrates for surface-enhanced Raman and resonant Raman scattering (SER(R)S) and their application in detecting and differentiating mutations in DNA sequences. SSV substrates are fabricated using the colloidal crystal templating strategy which has been optimized, improved and extended during ...
openaire   +1 more source

Gαi1/3 Is a Novel Regulatory Target for RANKL Signal Transduction and Osteoporosis

Advanced Science, EarlyView.
ABSTRACT Osteoporosis, characterized by progressive bone loss and increased fracture risk, is a growing concern as the population ages. Current treatments, though advanced, remain limited, underscoring the necessity for novel therapeutic targets. Recent studies have shown that the immune system plays a key role in osteoporosis, with osteoclasts driving
Chaowen Bai, Mingchao Zhang, Le Liu, Lide Tao, Chenyang Xu, Hao Chai, Xin Shi, Yin Wang, Xiaopei Zhang, Qiong Chen, Dong Liu, Jinyu Bai, Chang She, Xiaozhong Zhou, Cong Cao, Huajian Shan   +15 more
wiley   +1 more source

Acercamiento histórico, político y pedagógico al concepto de emancipación.

Revista Kavilando, 2018
El ser humano está llamado a conquistar su humanidad liberándose de las ataduras que minimizan su existencia. La totalidad o plenitud de la humana condición sólo se conquista en la lucha constante y colectiva por la destrucción de las cadenas, de las ...
Diego Alejandro Muñoz Gaviria, Andrés Klaus Runge Peña   +1 more
doaj  

Meios alternativos de solução de conflitos na administração pública

Revista de Doutrina Jurídica
Objetivo: o objetivo deste estudo é analisar se a obrigatoriedade da utilização dos meios alternativos de solução de conflitos (conciliação e mediação) por parte da Administração Pública pode ser considerada um direito fundamental do cidadão, e não ...
Acácia Regina Soares de Sá
doaj   +1 more source

Extracellular Vesicles of Streptococcus anginosus Mediate Gastritis via Epithelial Barrier Disruption and Macrophage‐driven Inflammation

Advanced Science, EarlyView.
Streptococcus anginosus extracellular vesicles (SA‐EVs) accumulate in gastric tissue, disrupt epithelial tight junctions, and induce gastritis characterized by neutrophil infiltration and elevated cytokines (TNF‐α, IL‐6, IL‐17A). Proteomics identifies TMPC and FBP62 as key SA‐EVs virulence factors; their genetic deletion attenuates inflammation ...
Ying Gong, Lina Duan, Jie Xiao, Yulu Deng, Hongxia Wang, Yajie Zhang, Xiumei Hu, Haifang Wang, Taixue An, Xin Li, Yurong Qiu, Lei Zheng, Haixia Li   +12 more
wiley   +1 more source

Single‐Cell Metabolic Imaging and Digital Scoring of Fat Tissue Remodeling by Label‐Free Metabolic Microscopy

Advanced Science, EarlyView.
Mid‐infrared optoacoustic microscopy (MiROM) acquires lipid‐ and protein‐ associated vibrational contrast in intact fat tissue without dyes, preserving native tissue architecture. Through lateral and axial segmentation, MiROM tracks intrinsic intracellular changes during postnatal remodeling. A quantitative spatial analysis tool (Q‐SAT) maps white‐ and
Myeongseop Kim, Constantin Berger, Alexander Wolf, Alina Peteranderl, Martin Klingenspor, Vasilis Ntziachristos, Yongguo Li, Miguel A. Pleitez   +7 more
wiley   +1 more source

Aproximación conceptual al “acceso efectivo a la administración de justicia” a partir de la teoría de la acción procesal

Revista de Derecho Privado (Bogota. 1997), 2013
La teoría de la acción procesal en su sentido abstracto puede servir de fundamento para la construcción conceptual del derecho fundamental al acceso efectivo a la administración de justicia, puesto que solo bajo dicha concepción es posible afirmar que ...
Fredy Hernando Toscano López
doaj   +2 more sources

O fundamento do conhecimento em L’être et le néant = The foundation of knowledge in L’être et le néant

Veritas, 2018
Pretendemos analisar neste artigo o fundamento ontofenomenológico do conhecimento em L’être et le néant (1943). Como veremos, o conhecimento será concebido a partir de uma negação de tipo interna definida como relação ontológica fundamental entre ser ...
Fujiwara, Gustavo
doaj