Results 41 to 50 of about 3,455,877 (273)
Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source
La exhibición de la intimidad como estrategia de inclusión social entre los jóvenes y adolescentes
Entretextos, 2015 Las comunidades virtuales, las redes sociales on line y el celular se han legitimado entre los adolescentes como las formas de inclusión social por excelencia.
Rosalía Winocur
doaj +1 more source
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
Metodologias para o ensino de astronomia e Física através da construção de telescópios
Caderno Brasileiro de Ensino de Física, 2008 Este trabalho propõe a construção manual de telescópios refletores como ferramenta didática para o ensino de Física e Astronomia. Cada etapa da construção pode ser aliada a conteúdos de óptica geométrica e óptica Física com abordagens diferentes ...
Tamara de O. Bernardes +2 more
doaj +1 more source
Surface Enhanced Raman Scattering (SERS): From Fundamental Mechanism to Bio-Analytics Tools [PDF]
Nano Biomedicine and Engineering, 2016 This review discusses the surface-enhanced Raman scattering (SERS) with efficiencies enhanced by as much as 1014-1015 fold as well as a SERS cross section on the order of 10-17-10-16 cm2/molecule. Despite the existing controversy on the origin of the enhancement, SERS effect offers new opportunities for spectroscopic detection of single molecules near ...
Xiao Zhi, Li Lin, Di Chen
openaire +2 more sources
Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics
FEBS Open Bio, EarlyView.Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini +2 more
wiley +1 more source
Homologous expression and purification of human HAX‐1 for structural studies
FEBS Open Bio, EarlyView.This research protocol provides detailed instructions for cloning, expressing, and purifying large quantities of the intrinsically disordered human HAX‐1 protein, N‐terminally fused to a cleavable superfolder GFP, from mammalian cells. HAX‐1 is predicted to undergo posttranslational modifications and to interact with membranes, various cellular ...
Mariana Grieben
wiley +1 more source
É eticamente aceitavel o uso de recém cadaveres no ensino de procedimentos médicos?
Revista do Colégio Brasileiro de CirurgiõesA utilização de recém-cadáveres no ensino de procedimentos médicos ocorre com frequência desconhecida. Na área cirúrgica o treinamento de habilidades tem fundamental importância devido à necessidade de procedimentos invasivos próprios dos cirurgiões ...
José Marques Filho
doaj +1 more source
FEBS Open Bio, EarlyView.The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan +6 more
wiley +1 more source
El carisma de un joven profesor inconformista: la fuerza y la magia de Ser y tiempo
Differenz, 2014 Todavía hoy en día, Ser y tiempo sigue siendo un título mágico, compuesto de dos palabras intrigantes que, en su compleja sencillez, intenta repensar la pregunta fundamental de la historia de la filosofía: la pregunta por el ser.
Jesús Adrián Escudero
doaj +1 more source