Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
FEBS Letters, EarlyView.The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source
En el umbral : ideas para una definición filosófica del periodismo [PDF]
, 2016 En la ponencia se intenta dilucidar la relación que el periodismo establece tanto con el concepto de apariencia como con el de realidad, adoptando para ello un punto de vista estrictamente filosófico.
Murcia Serrano, Inmaculada
core
Standard and derived Planck quantities: selected analysis and derivations
, 2010 We provide an overview of the fundamental units of physical quantities determined naturally by the values of fundamental constants of nature. We discuss a comparison between the 'Planck units', now widely used in theoretical physics and the pre-quantum ...
C. S. Unnikrishnan +16 more
core +1 more source
Similarity hypotheses for the atmospheric surface layer expressed by non-dimensional characteristic invariants - a review [PDF]
, 2009 In this paper, similarity hypotheses for the atmospheric surface layer (ASL) are reviewed using nondimensional characteristic invariants, referred to as π -numbers.
Herbert, Fritz, Kramm, Gerhard
core +1 more source
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
¿Prevalece un vínculo, objetivo, entre la percepción sensible y los conceptos? [PDF]
, 2014 La imposibilidad de alcanzar contenidos cognitivos por medio de la percepción sensible actualmente puede ser cuestionada. Se busca reconsiderar que el conocimiento obtenido por medio de la percepción sensible guarde contenidos de objetividad, expresables
DELGADO WISE, MARTHA DOLORES +1 more
core
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Protocolo diagnóstico y seguimiento de la prevalencia e incidencia del virus del papiloma humano (vph) y las anormalidades citológicas de la mucosa anal de hombres que tienen sexo con hombres (hsh) e infección por el virus de la inmunodeficiencia humana (vih) [PDF]
, 2012 La citologia anal és un mètode sensible en el despistatge de la neoplàsia de canal anal i similar a la biòpsia dirigida mitjançant rectoscopi i tinció amb àcid acètic al 5%, sobretot en lesions d'alt grau de malignitat; a més de ser una prova adequada en
Rivero Rodríguez, Maria del Mar +2 more
core
Training samples in objective Bayesian model selection
, 2004 Central to several objective approaches to Bayesian model selection is the use of training samples (subsets of the data), so as to allow utilization of improper objective priors.
Berger, James O., Pericchi, Luis R.
core +3 more sources
Netebaon joi: La semiótica cósmica shipibo-konibo
América sin NombreEl presente artículo plantea una reflexión semiótica desde una perspectiva shipibo-konibo, de la Amazonía peruana. Desde la comprensión de los sabios amerindios, todos los seres vivos (tanto del mundo sensible como suprasensible) participan del lenguaje;
Pedro Martín Favaron Peyón
semanticscholar +1 more source