Results 101 to 110 of about 556,751 (253)

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

The relationship between parent-child relationship and prosocial behavior among Chinese children: the mediating roles of labor participation and sense of social responsibility

Frontiers in Psychology
PurposeBased on ecosystem theory, this study explores the relationship between parent-child relationships and prosocial behavior among primary students, as well as the mediating effect of labor participation and sense of social responsibility.MethodsA ...
Xurui Zhang, Weiwei Tang, Qingqing Miao, Haitian Lan, Fangqi Wang, Shiqi Wang, Jing Tao, Shuiping Deng, Rui Wang, Jinhua Gu, Jinhua Gu, Cheng Chen, Zinan Zhang, Xin Cao   +13 more
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Resilience after the quake: life engagement and humor as pathways to trauma recovery

Frontiers in Psychology
BackgroundEarthquakes are frequently associated with elevated levels of psychological trauma, particularly among vulnerable groups. In this context, understanding the conceptual pathways and relational processes through which individuals cope becomes an ...
Şıhmehmet Yiğit, Oğulcan Usuflu, Mehmet Behzat Turan, Sevim Kır, Hakkı Ulucan, İbrahim Dalbudak, Osman Pepe, Gül Bahar Bayıroğlu   +7 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Mediation- the Alternative Processes Lengthy and Expensive [PDF]

Adopt a law on mediation and the mediator profession organization started and the idea that mediation is an important theme of the strategy for justice reform a priority in the Action Plan for implementing the judicial reform strategy 2005-2007.
Bobaru, Daniela
core  

How Is Bullying Victimization Associated with Depressive Symptoms Among Multicultural Adolescents in South Korea? A Serial Mediation and Network Analysis of Acculturative Stress and Ego-Resiliency

Behavioral Sciences
Bullying victimization is consistently associated with depressive symptoms among adolescents, yet the psychological processes underlying this association remain insufficiently understood, particularly among multicultural adolescents.
Zhenping Jiang, Xiaochen Li, Bum-Young Park, Meng Chen   +3 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source