Results 121 to 130 of about 14,246,728 (251)

Factors influencing HPV vaccination intention and uptake behaviors among medical students based on the health belief model and vaccine hesitancy theory: a cross-sectional study

Frontiers in Public Health
BackgroundHPV infection is the leading cause of cervical cancer. HPV vaccination coverage among young people in China remains low. Medical students, as a high-risk group and future health educators, are critical for cervical cancer control.MethodsA ...
Hao Wang, Shiqi Zhao, Hua Lin, Siyu Zhao, Dehui Yin   +4 more
doaj   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Investigation of Certain Cognitive and Metacognitive Factors Affecting Anxiety and Depression Symptoms Through Parallel Serial Mediation Models

Psikiyatride Güncel Yaklaşımlar
Objective: This study aims to investigate the parallel serial mediating effects of cognitive flexibility, attentional control, and worry in the relationship between rumination—which has been repeatedly proven to persist in the etiology of depression—and ...
Zeynep Erdoğan Yıldırım, Emine Aktaş, Ceylan Hasanoğlu, Serap Tekinsav Sütcü   +3 more
doaj   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

The association between smartphone addiction and creativity in Chinese college students: the chain mediating effects of depression and executive function

BMC Psychiatry
Background Smartphone addiction has emerged as a widespread public health concern, especially among college students. This study examines the association between smartphone addiction and creativity among Chinese college students, as well as the ...
Wenfu Li, Jinmei Liu, Xia Liu, Yao Ge, Yan Wang, Aoxue Zhang   +5 more
doaj   +1 more source

From social exclusion to interpersonal alienation among Chinese college students: the sequential mediating roles of social avoidance and self-disclosure inhibition

Frontiers in Psychology
BackgroundSocial exclusion—being ignored, rejected, or excluded in social interactions—is a prevalent interpersonal stressor among college students, yet the specific mechanisms linking exclusion to long-term interpersonal difficulties remain poorly ...
Yi Liu, Pan Chen, Peng Lei, Wei Tang
doaj   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

MEDIATION IN THE NORWEGIAN LAND CONSOLIDATION COURTS [PDF]

In Norway land consolidation is organized entirely within the judicial system. This paper describes how land consolidation courts work, and examines mediation activities in the courts.
Sky, Per Kare, Rognes, Jorn
core  

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source