Results 71 to 80 of about 9,522,068 (262)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Whatever happened to William Osler's library?
Journal of the Canadian Health Libraries Association, 2006 Sir William Osler bequeathed his library to McGill University in 1919, and the 8000 volumes arrived in Montreal a decade later. Then, as now, the collection consisted of both primary works (rare books) and secondary commentaries, and current works on the
Christopher Lyons, David S Crawford
doaj +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Awareness, Accessibility and Use of Serial Publications among Undergraduate Students of Adeyemi College of Education, Ondo [PDF]
, 2019 The research was on awareness, accessibility and use of serial publications among undergraduate students of Adeyemi College of Education, Ondo. Five research questions guided the study.
Olubiyo, Peter Olubunmi +2 more
core +2 more sources
A Survey on Citation Analysis and Journals Citation Report and its Application in Selecting English Publications [PDF]
تحقیقات اطلاعرسانی و کتابخانههای عمومی, 2009 Nowadays, English publications are considered as one of the significant and essential resources in university libraries. Enhancement of the price of publications along with the increase in number of published journals has made it difficult for libraries ...
Mahnaz Rizan
doaj
FEBS Letters, EarlyView.Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell +2 more
wiley +1 more source
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
Rivista di Storia dell'EducazionePicturebooks (albums pour la jeunesse) first achieve an identity as media in their own right in the 19th century. Thanks to authors from different European countries and from the United States, the early 20th century brings about a transition from ...
Luca Ganzerla
doaj +1 more source