Results 61 to 70 of about 9,522,068 (262)
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
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Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Cadernos de Saúde PúblicaEste trabalho consiste em uma revisão de 209 artigos originais publicados pelos Arquivos Brasileiros de Nutrição (1944/1968), um periódico editado pelo médico-nutrólogo Josué de Castro, diretor-fundador do Instituto de Nutrição da Universidade do Brasil (
Francisco de Assis Guedes de Vasconcelos
doaj +2 more sources
Applications of Bacteriophages in the Treatment of Localized Infections in Humans
Frontiers in Microbiology, 2018 In the recent years, multidrug-resistant bacteria have become a global threat, and phage therapy may to be used as an alternative to antibiotics or, at least, as a supplementary approach to treatment of some bacterial infections.
Vera V. Morozova +2 more
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Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Die Grenzboten on its Way to Virtual Research Environments and Infrastructures
Journal of European Periodical Studies, 2019 The State and University Library Bremen (SuUB) is dedicated to the digitization of its historical collections. Digitization is an important instrument for improving the accessibility of valuable information contained in fragile historical documents.
Manfred Nölte, Martin Blenkle
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FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Revista Facultad de Ingeniería Universidad de Antioquia, 2015 Since March 12, this year, the Revista Facultad de Ingeniería has been assigned an online ISSN (e-ISSN: 2422-2844), which can be seen at the top of this issue’s cover. Considering that digital publications are in state of tremendous growth, we hopefully
Maryory Astrid Gómez Botero
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Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Bulletin KNOB, 2015 During the eighteenth century there appeared a very substantial illustrated historical-topographical description of the Republic, De Tegenwoordige Staat der Vereenigde Nederlanden (The Current State of the United Netherlands, 23 vol., 1738-1803 ...
Everhard Korthals Altes
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