Results 91 to 100 of about 2,985 (286)
Switch Facade: Seriality and Urbanism
, 2014 The thesis proposes re-cladding the Smithson’s Economist Building to demonstrate a heterogeneous serial facade and explore the relationship between facades and urbanism.
Hohman, Alexander
core
Seriality, Repetition and Innovation in Breaking Bad’s Recaps and Teasers
Cinergie, 2017 In this article we face some rhetorical and socio-semiotical operations that contribute to build the serial narrative ecosystems, focusing on the Breaking Bad case.
Nicola M. Dusi
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
L’idiota Puškin e il saggio Stalin. Aneddotica e strategie di demitizzazione in Charms e Prigov
eSamizdat, 2023 The avant-garde literary group OBĖRIU, with its poetics of the absurd, alogism and grotesque, had a great influence on later Soviet Russian literature and on neo-avant-garde movements as well. This paper investigates the connection between OBĖRIU and the
Alice Bravin
doaj
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Ending(s), Seriality And Interdiscursivity
Sillages Critiques, 2018 This article examines the issue of the collection of short-stories in the works of Jean Rhys and Janet Frame. Within its composition itself, it stages the necessary yet paradoxical repetition of endings, along with the incessant regeneration and ...
Elsa Lorphelin Blaise
doaj +1 more source
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source