Results 81 to 90 of about 9,366 (302)

Returning to the Scene: Seriality and the Serial Killer

open access: yesOpen Screens, 2020
This article reads the perennial popularity of true crime products as symptomatic of repression and cultural trauma. Providing a close-reading of gender representation in the popular Netflix series Mindhunter, the author meditates on the postmodern ...
Katie Jones
doaj   +2 more sources

Stefan Roski, Bolzano’s Conception of Grounding [PDF]

open access: yes, 2017
I review Stefan Roski's "Bolzano's Conception of Grounding"
Sandstad, Petter
core  

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

Parametric Constructive Kripke-Semantics for Standard Multi-Agent Belief and Knowledge (Knowledge As Unbiased Belief)

open access: yes, 2012
We propose parametric constructive Kripke-semantics for multi-agent KD45-belief and S5-knowledge in terms of elementary set-theoretic constructions of two basic functional building blocks, namely bias (or viewpoint) and visibility, functioning also as ...
Kramer, Simon, Sack, Joshua
core  

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

open access: yesFEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel   +13 more
wiley   +1 more source

Le son donné. Une fabrique archivistique

open access: yesTracés, 2019
This article deals with the specificities and uses of sound data produced in the particular context of an experiment led in Brussels over the last twenty years by the BNA-BBOT organization.
Séverine Janssen, Camille Noûs
doaj   +1 more source

Sequent systems for negative modalities

open access: yes, 2017
Non-classical negations may fail to be contradictory-forming operators in more than one way, and they often fail also to respect fundamental meta-logical properties such as the replacement property. Such drawbacks are witnessed by intricate semantics and
Lahav, Ori, Marcos, João, Zohar, Yoni
core   +1 more source

AAA+ protein unfoldases—the Moirai of the proteome

open access: yesFEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

Arrigo Lora Totino, “architetto di parole”: dalle verbotetture ai cromofonemi

open access: yesLea, 2018
The paper proposes an analysis of the first phase of the artistic-literary activity of Arrigo Lora Totino, from the review Antipiugiù to the “concrete turn” of the 1960s, in relation to the diffusion of concrete experimentation in Germany and Brasil, and
Teresa Spignoli
doaj   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

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