Results 81 to 90 of about 88,119 (330)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Repetition and variation in Milan Adamčiak’s typewriter concrete poetry [PDF]

Slovenska Literatura
The contribution deals with the typewritten concrete poetry of the intermedia artist Milan Adamčiak (1946 – 2017), which was created in the second half of the 1960s.
Jaroslav Šrank
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Parametric Constructive Kripke-Semantics for Standard Multi-Agent Belief and Knowledge (Knowledge As Unbiased Belief)

, 2012
We propose parametric constructive Kripke-semantics for multi-agent KD45-belief and S5-knowledge in terms of elementary set-theoretic constructions of two basic functional building blocks, namely bias (or viewpoint) and visibility, functioning also as ...
Kramer, Simon, Sack, Joshua
core  

Doing time and motion diffractively: Academic life everywhere and all the time [PDF]

, 2018
This article offers a diffractive methodological intervention into workplace studies of academic life. In its engagement of a playful, performative research and writing practice the article speaks back to technocratic organisational and sociological ...
Alaimo S., Barthes R., Carol A. Taylor, Daly M., Deleuze G., Foucault M, Jackson A., Koro-Ljungberg M., Mathews H., Parikka J., Snaza N., Stengers I., Susanne Gannon, Taylor C. A.   +13 more
core   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Pour une « spaciologie » des séries télévisées, la sérialité autrement : analyse des espaces dans Hannibal de Bryan Fuller (NBC, 2013-2015)

TV Series, 2019
The purpose of this article is to analyze the construction of television series spaces as a specificity of televisual seriality through the study of television series Hannibal, while highlighting the heuristic value of this approach.
Sophie Lorgeré
doaj   +1 more source

Stefan Roski, Bolzano’s Conception of Grounding [PDF]

, 2017
I review Stefan Roski's "Bolzano's Conception of Grounding"
Sandstad, Petter
core  

Proving Craig and Lyndon Interpolation Using Labelled Sequent Calculi

, 2016
We have recently presented a general method of proving the fundamental logical properties of Craig and Lyndon Interpolation (IPs) by induction on derivations in a wide class of internal sequent calculi, including sequents, hypersequents, and nested ...
A Herzig, B Cate ten, E Amir, J Brotherston, LL Maksimova, M Bílková, M Fitting, M Marx, R Dyckhoff, R Kuznets, R Kuznets, S Negri, SA Kripke   +12 more
core   +1 more source