Results 81 to 90 of about 711 (245)
Ending(s), Seriality And Interdiscursivity
Sillages Critiques, 2018 This article examines the issue of the collection of short-stories in the works of Jean Rhys and Janet Frame. Within its composition itself, it stages the necessary yet paradoxical repetition of endings, along with the incessant regeneration and ...
Elsa Lorphelin Blaise
doaj +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
La « mise en pièce » de Renée : Genèse et impératifs de l’adaptation d’Émile Zola
Carnets, 2018 Usually known due to his journalistic commitment and his famous novels, Emile Zola succumbs to the « theatrical temptation » described by Philippe Chardin.
Nejma Omari
doaj +1 more source
Effect of chemotherapy on passenger mutations in metastatic colorectal cancer
Molecular Oncology, EarlyView.Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui +6 more
wiley +1 more source
Quality assessment of automatically planned O-Ring linac SBRT plans for pelvic lymph node metastases, finding the optimal minimum target size by comparison with robotic SBRT. [PDF]
J Appl Clin Med Phys, 2023 Hernández KVD +2 more
europepmc +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source
The critical temporalities of serial migration and family social reproduction in Southeast Asia. [PDF]
Time Soc, 2023 Yeoh BSA +3 more
europepmc +1 more source
Biometrika, 1968 SUMMARY Serial factorial designs are designs for long-term experiments with one or more basic treatments repeated as separate factors every year. The designs are cyclic, with essentially the same structure in any period of successive years. For example, three rates of a single basic treatment (e.g.
openaire +2 more sources
Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source