Results 91 to 100 of about 476,931 (298)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
HELIN Serials Committee Annual Report for June 2009
, 2009 Annual Report of the Serials Committee of the HELIN Consortium for 2008 ...
HELIN Consortium. Serials Committee
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FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
HELIN Serials Committee minutes for 10/24/05
, 2005 Minutes of the Serials Committee of the HELIN Consortium for October ...
HELIN Consortium. Serials Committee
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Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
HELIN Serials Committee minutes for 6/10/08
, 2008 Minutes of the Serials Committee of the HELIN Consortium for June ...
HELIN Consortium. Serials Committee
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Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
HELIN Serials Committee minutes for 10/09/07
, 2007 Minutes of the Serials Committee of the HELIN Consortium for October ...
HELIN Consortium. Serials Committee
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Fantasy Pricing – An Interview with Selden Lamoureux
In the Library with the Lead Pipe, 2010 When I asked Selden Lamoureux, Electronic Serials Librarian at the North Carolina State University Libraries, “what are the most challenging issues for electronic serials librarians today?” we launched into a fascinating conversation about a topic that ...
Selden Lamoureux
doaj
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source