Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
Biometrika, 1968 SUMMARY Serial factorial designs are designs for long-term experiments with one or more basic treatments repeated as separate factors every year. The designs are cyclic, with essentially the same structure in any period of successive years. For example, three rates of a single basic treatment (e.g.
openaire +2 more sources
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Journal subscriptions in the changing landscape: Are they needed? [PDF]
Indian J Urol, 2023 Goel A.
europepmc +1 more source
Concurrent Error Detection in Bit-Serial Normal Basis Multiplication Over ${\rm GF}(2^{m})$ Using Multiple Parity Prediction Schemes [PDF]
, 2009 Chiou‐Yng Lee +2 more
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The information value chain: emerging models for procuring electronic publications [PDF]
, 2000 The first part of this paper examines the information supply chain and some of its concepts; particular attention is paid to features differentiating electronic from printed information. The second part discusses the procurement process and, in the light
Ball, David, Wright, Susan
core
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Teacher's Perspectives About Tobacco Consumption and Its Prevention Among Students From Western Maharashtra, India: A Qualitative Study. [PDF]
Cureus, 2023 Kawalkar U +5 more
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, 1994 Contains fulltext : 4217.pdf (Publisher’s version ) (Open Access)
Muysken, P.C., Veenstra, T.
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The role of histone modifications in transcription regulation upon DNA damage
FEBS Letters, EarlyView.This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley +1 more source