Results 101 to 110 of about 7,221,536 (339)
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris +10 more
wiley +1 more source
ComhumanitasEl objetivo de este texto es mostrar que el auge y romantización, en series o películas, de personajes inspirados en mafiosos o narcotraficantes es posible debido a que estos no proponen un cambio en el sistema bajo consignas de reivindicación social ...
Sofía Gómez Sánchez
doaj +1 more source
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
CadmusInterest in system change is rising, driven largely by growing awareness that flawed economic and political systems are the root causes of climate change and other major challenges.
Frank Dixon
doaj
The cyclization of epics about the Forty Batyrs and the epic tradition
Uluslararası Türk Lehçe Araştırmaları DergisiThe “Forty Batyrs” epic cycle began to attract more attention with the collapse of the Soviet Union. The epics it includes, like its name, have not yet been properly learned in the scientific world.
Gumru
doaj +1 more source
Pediatric Injury Transfer Patterns During the COVID-19 Pandemic: An Interrupted time Series Analysis [PDF]
, 2022 Katherine T. Flynn‐O’Brien +19 more
openalex +1 more source