Results 121 to 130 of about 7,591,914 (316)
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Наука телевидения, 2017 The article is devoted to the arrangement of the modern realities of the fabulous material by the example of the popular American TV series «Grimm» and «Once Upon a Time in a Fairytale», where through the ambivalent relationship of time and space ...
SPUTNITSKAYA N.Y. / СПУТНИЦКАЯ Н.Ю.
doaj
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Ikhtisar, soal ujian dan penyelesaiannya hidrology/ Cipta Science Series
123 hal.: ill.; 21 ...
Cipta Science Series
core
Aequationes Mathematicae, 1983 Let \(L^ 2\) denote the Banach algebra of Lebesgue-integrable functions \(f: [0,\omega)\to {\mathbb{C}}\) with convolution product ''*'', \(\Omega\) a nonfinite compact subset of the right half-plane Re s\(>0\) and the space of generalized functions \(X_{\Omega}\) the completion of \(L^ 1\) with respect to the norm \[ | x|_{\Omega}=\max_{s\in \Omega}| \
openaire +2 more sources
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
The Transformation of a Lagrangian Series into a Newtonian Series [PDF]
Proceedings of the National Academy of Sciences, 1939 openaire +3 more sources
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source