Results 131 to 140 of about 7,591,914 (316)

19890407: Marshall Artists Series, 1978-1987

open access: yes, 1989
These items include materials from the office of the Artist Series at Marshall University from 1978-1989. Items were received in 1989. Items include business operational materials for the Office, including general bills, bulk mailings, the 50th ...
Marshall Artist Series
core  

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

open access: yesMolecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington   +10 more
wiley   +1 more source

Imágenes para 25 habitaciones: Office KGDVS

open access: yesARQ, 2012
A partir de una colección de habitaciones idénticas en planta y topológicamente equivalentes, tres imágenes dan cuenta de la crítica relación entre el espacio y los objetos contenidos en él, y de los matices de habitabilidad posibles en un campo neutro.A
Kersten Geers, David van Severen
doaj  

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

open access: yesMolecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq   +8 more
wiley   +1 more source

American Writing Today

open access: yes, 1982
339 hal.;22 ...
Forum Series
core  

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

open access: yesMolecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach   +9 more
wiley   +1 more source

Resurssiviisaaksi ihmislähtöisin keinoin -hankkeen sisällöllinen loppuraportti [PDF]

open access: yes, 2022
Lotta Harjula, Pekka Heikkinen, Johanna Hyrkäs, Tanja Pöyhönen
core   +1 more source

Global System Change: A Whole System, Nature-Based Framework for Sustainability, System Change and Responsible Investing

open access: yesCadmus
Interest in system change is rising, driven largely by growing awareness that flawed economic and political systems are the root causes of climate change and other major challenges.
Frank Dixon
doaj  

CEACAM1 participation in breast cancer progression

open access: yesMolecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin   +3 more
wiley   +1 more source

The Role of Narrator in Serial Radio Fiction: The Case of ‘Taxi Key’

open access: yesIndex Comunicación, 2019
In spite of the prominence acquired by dialogues among characters in creating a series, we cannot ignore that radio speech can be represented in turn by the narrators's presence.
Elisa Arias García
doaj  

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