Results 41 to 50 of about 7,852,908 (296)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Half-Bridge Full-Bridge AC–DC Resonant Converter for Bi-Directional EV Charger

IEEE Access, 2023
A new topology and controller based on single-stage AC-DC resonant converter, without Electrolytic capacitors (E-cap), for bi-directional EV battery chargers is proposed in this paper.
Behnam Koushki, Praveen Jain, Alireza Bakhshai   +2 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

New control algorithm for single-phase series active power filter [PDF]

, 2015
This paper presents a single-phase Series Active Power Filter (Series APF) for mitigation of the load voltage harmonic content, while maintaining the voltage on the DC side regulated without the support of a voltage source.
Freitas, Manuel S., Afonso, João L., Teixeira, Nuno F., Pinto, J. G.   +3 more
core   +1 more source

Active Power Filter Design by a Novel Approach of Multi-Objective Optimization [PDF]

Journal of Operation and Automation in Power Engineering, 2007
This paper presents an innovative active power filter design method to simultaneously compensate the current harmonics and reactive power of a nonlinear load.
H. R. Imanijajarmi, A. Mohamed, H. Shareef   +2 more
doaj  

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Fuzzy Sliding Mode Based Series Hybrid Active Power Filter for Power Quality Enhancement

Advances in Fuzzy Systems, 2018
This paper contributes an innovative gating signal generation technique based on fuzzy sliding mode pulse width modulation (FSMPWM) with a Series Hybrid Active Power Filter (SEHAPF) for reducing the total harmonic distortion (THD).
Soumya Ranjan Das, Prakash K. Ray, Asit Mohanty   +2 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Control methods and compensation characteristics of a series active filter for neutral conductor

Electrical Engineering in Japan, 2004
AbstractWith an increase in the number of electronic devices, such as personal computers, connected to power distribution lines in commercial buildings, problems associated with their use, such as voltage distortion on utility outlets and excessive neutral current on the distribution lines, become more and more serious. This paper shows control methods
Shigenori Inoue, Toshihisa Shimizu, Keiji Wada   +2 more
openaire   +2 more sources

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source