Results 41 to 50 of about 8,309,634 (293)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Band Pass Filters Based on GaN/Si Lumped-Element SAW Resonators Operating at Frequencies Above 5 GHz

IEEE Access, 2018
This paper reports on a GaN/Si surface acoustic wave (SAW) impedance element filter operating in the few gigahertz region. The PI-type filter consists of three SAW resonators with the same digit/interdigit widths, integrated with series/parallel planar ...
Dan Neculoiu, Alina-Cristina Bunea, Adrian M. Dinescu, Leo A. Farhat   +3 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Harmonic Mitigation in a Smart Grid Using a PV-Powered Series Active Power Filter [PDF]

E3S Web of Conferences
The rising integration of photovoltaic PV sources within SMART GRIDS introduces significant challenges related to power quality PQ, especially due to harmonic distortions that can address grid. Stability, high power quality, and optimal efficiency of all
El Ouardi Said, Lakhal Yassine, Mechbouh Abdelfattah, Baghli Fatima Zahra, Saadaoui Ilham, Samagassi Soulaimane   +5 more
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Half-Bridge Full-Bridge AC–DC Resonant Converter for Bi-Directional EV Charger

IEEE Access, 2023
A new topology and controller based on single-stage AC-DC resonant converter, without Electrolytic capacitors (E-cap), for bi-directional EV battery chargers is proposed in this paper.
Behnam Koushki, Praveen Jain, Alireza Bakhshai   +2 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Active Power Filter Design by a Novel Approach of Multi-Objective Optimization [PDF]

Journal of Operation and Automation in Power Engineering, 2007
This paper presents an innovative active power filter design method to simultaneously compensate the current harmonics and reactive power of a nonlinear load.
H. R. Imanijajarmi, A. Mohamed, H. Shareef   +2 more
doaj  

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Fuzzy Sliding Mode Based Series Hybrid Active Power Filter for Power Quality Enhancement

Advances in Fuzzy Systems, 2018
This paper contributes an innovative gating signal generation technique based on fuzzy sliding mode pulse width modulation (FSMPWM) with a Series Hybrid Active Power Filter (SEHAPF) for reducing the total harmonic distortion (THD).
Soumya Ranjan Das, Prakash K. Ray, Asit Mohanty   +2 more
doaj   +1 more source