Results 121 to 130 of about 8,556,345 (307)

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

open access: yesMolecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur   +11 more
wiley   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

open access: yesMolecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington   +10 more
wiley   +1 more source

Optimal solution of nonlinear equations [PDF]

open access: yes, 1985
journal articleWe survey recent worst case complexity results for the solution of nonlinear equations. Notes on worst and average case analysis of iterative algorithms and a bibliography of the subject are also ...
Optimal solution; Nonlinear equations   +1 more
core  

Power Series Solution for Korteweg-de Vries Equation

open access: yesTrends in Computational and Applied Mathematics
We apply the similarity method to the Korteweg-de Vries equation, where we obtain a new equation, in terms of similarity variable. We use the power series method, getting the similarity solution, which is exemplified graphically by particular cases.
F. S. Costa   +3 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

open access: yesMolecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq   +8 more
wiley   +1 more source

20081104: Marshall Artist Series Programs, 1937-2002 [PDF]

open access: yes
These items include materials from the office of the Artist Series at Marshall University from 1937-2002. Items were received in 2008 and include notable materials from or about program brochures the Artist Series produced. This is not an exhaustive list.
Marshall Artist Series
core  

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

open access: yesMolecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach   +9 more
wiley   +1 more source

Classic Film Series showing (poster)

open access: yes, 2007
Poster advertising a showing from the Classic Film Series group in February, 2024.
Classic Film Series
core  

Numerical solution for fractional Neumann series equations

open access: yesAin Shams Engineering Journal
This study focuses on fractional differential equations defined by the Neumann series operator. The inverse of the fractional integral operator (1−α)I0+αIα is associated with a MABC operator.
Dumitru Baleanu, Babak Shiri
doaj   +1 more source

On the series solutions of integral equations in scattering

open access: yesComptes Rendus. Mathématique
We study the validity of the Neumann or Born series approach in solving the Helmholtz equation and coefficient identification in related inverse scattering problems. Precisely, we derive a sufficient and necessary condition under which the series is strongly convergent. We also investigate the rate of convergence of the series.
Karamehmedovic, Mirza; id_orcid 0000-0003-0038-9020   +1 more
openaire   +5 more sources

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