Results 31 to 40 of about 4,202,279 (295)
Design and analysis strategies for robust microbiome ageing research
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Tendencias de los días con precipitación en la cuenca de Sóller (Mallorca, España)
A partir de los datos diarios de lluvia en dos estaciones de una cuenca de 50km2 en la isla de Mallorca se ha estudiado la distribución anual de estas jornadas, así como su reparto estacional en las décadas finales del siglo XX.
Joan Rosselló Geli
doaj +2 more sources
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
Definir el enfoque cuantitativo de la previsión Caracterizar los modelos de series temporales Identificar los componentes en los que se descomponen de las series temporaleshttps://polimedia.upv.es/visor/?id=de0a2100-a0d7-11ea-af36-4f540accf315Andrés ...
Andres, B.
core
FUNDAMENTO: En la última década se vienen realizando estudios que identifican una asociación entre la contaminación atmosférica y la mortalidad por debajo de los niveles permitidos de contaminación.
Bellido Blasco Juan B +5 more
doaj
: Diarrhea by rotavirus is one of the main causes of mortality in children in developing countries, although the hospitalization rates (HR) for acute diarrhea have been found to have fallen since the introduction of the rotavirus vaccine.
Maria de Lourdes Teixeira Masukawa +5 more
doaj +1 more source
Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley +1 more source
FUNDAMENTO: Los estudios realizados hasta la fecha sobre la posibilidad de que los contaminantes atmosféricos puedan tener efectos sobre la salud no han alcanzado resultados homogéneos.
Cañada Martínez Alvaro +5 more
doaj

