Results 31 to 40 of about 4,202,279 (295)

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

open access: yesFEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang   +4 more
wiley   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

open access: yesFEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Tendencias de los días con precipitación en la cuenca de Sóller (Mallorca, España)

open access: yesBoletín Geográfico, 2021
A partir de los datos diarios de lluvia en dos estaciones de una cuenca de 50km2 en la isla de Mallorca se ha estudiado la distribución anual de estas jornadas, así como su reparto estacional en las décadas finales del siglo XX.
Joan Rosselló Geli
doaj   +2 more sources

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

open access: yesFEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge   +6 more
wiley   +1 more source

Modelos de series temporales

open access: yes, 2020
Definir el enfoque cuantitativo de la previsión Caracterizar los modelos de series temporales Identificar los componentes en los que se descomponen de las series temporaleshttps://polimedia.upv.es/visor/?id=de0a2100-a0d7-11ea-af36-4f540accf315Andrés ...
Andres, B.
core  

Efectos a corto plazo de la contaminación atmosférica sobre la mortalidad : resultados del proyecto EMECAM en Castellón, 1991-95

open access: yesRevista Española de Salud Pública, 1999
FUNDAMENTO: En la última década se vienen realizando estudios que identifican una asociación entre la contaminación atmosférica y la mortalidad por debajo de los niveles permitidos de contaminación.
Bellido Blasco Juan B   +5 more
doaj  

Time series investigation of changes in seasonality of acute diarrhea hospitalizations before and after rotavirus vaccine in Southern Brazil

open access: yesCadernos de Saúde Pública
: Diarrhea by rotavirus is one of the main causes of mortality in children in developing countries, although the hospitalization rates (HR) for acute diarrhea have been found to have fallen since the introduction of the rotavirus vaccine.
Maria de Lourdes Teixeira Masukawa   +5 more
doaj   +1 more source

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

open access: yesFEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

Efectos a corto plazo de la contaminación atmosférica sobre la mortalidad: resultados del proyecto EMECAM en dos ciudades de Asturias

open access: yesRevista Española de Salud Pública, 1999
FUNDAMENTO: Los estudios realizados hasta la fecha sobre la posibilidad de que los contaminantes atmosféricos puedan tener efectos sobre la salud no han alcanzado resultados homogéneos.
Cañada Martínez Alvaro   +5 more
doaj  

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