Results 171 to 180 of about 1,010,564 (310)

D-serine metabolism enhances <i>Escherichia coli</i> fitness in the gut and could contribute to <i>Enterobacteriaceae</i> expansion in Crohn's disease patients. [PDF]

Curr Res Microb Sci
Moreira de Gouveia MI, Blanchot A, Garrivier A, Daniel J, Nguyen AL, Messager A, Bernalier-Donadille A, Jubelin G.   +7 more
europepmc   +1 more source

Time‐Controlled Refrigerated Stem Cell Therapy Mitigates Scleroderma Fibrosis via Modulation of Mitochondrial Autophagy and Gut Metabolism

Advanced Science, EarlyView.
This study established an RT‐MSCs‐based therapeutic approach for scleroderma in mice. RT‐MSCs attenuated fibrosis by regulating mitochondrial autophagy and restored gut microbiota homeostasis. Metabolomic analyses confirmed recovery of key metabolites, and RT‐MSCs demonstrated favorable lesion targeting and safety profiles.
Xue Xia, Chenfei Kong, Xiaoming Zhao, Naixu Shi, Jinlan Jiang, Ping Li   +5 more
wiley   +1 more source

PHGDH phosphorylation mediated by WNK1 serves as a dual marker of metabolic vulnerability and responsiveness to oxaliplatin treatment. [PDF]

Proc Natl Acad Sci U S A
Fang S, Jin G, Yan M, Song Y, Zhao S, Zhang C, Shao Y, Zhao K, Liu M, Wang Z, Jia X, Guo Q, Guo M, Wang M, Guo Z, Dong Z.   +15 more
europepmc   +1 more source

Halofuginone is a Molecular Glue Degrader of Integrin β4

Advanced Science, EarlyView.
Integrin β4 overexpression is linked to aggressive tumors and poor prognosis, but targeted therapies are lacking. We identified halofuginone (HF) as a molecular glue degrader that promotes integrin β4 degradation via the CRL4BWDR18 E3 ligase. HF suppresses tumor progression in vitro and in vivo, offering a new strategy for targeting oncogenic ...
Wei Gong, Di Yang, Junrui Tian, Yufei Chai, Tiantian Yu, Qingnan Wu, Yan Wang, Weimin Zhang, Qimin Zhan   +8 more
wiley   +1 more source

Association Between Serine Concentration and Coronary Heart Disease: A Case–Control Study

International Journal of General Medicine
Fangfang Fan,1,2,* Zhe Liang,1,2,* Zhihao Liu,1 Pengfei Sun,1 Lihua Hu,1 Jia Jia,1,2 Yan Zhang,1,2 Jianping Li1,2 1Department of Cardiology, Peking University First Hospital, Beijing, People’s Republic of China; 2Institute of Cardiovascular ...
Fan F, Liang Z, Liu Z, Sun P, Hu L, Jia J, Zhang Y, Li J   +7 more
doaj  

The mechanism of PKM2/HIF-1α axis polarizing TAMs by upregulating glucose-serine metabolism to promote melanoma progression. [PDF]

Front Immunol
Yang Y, Su P, Yang X, Liang N, Huang X, Sun Y, Chen C, Chen H, Li C, Yang J, Zhang N.   +10 more
europepmc   +1 more source

Cryo‐EM Structure Guided Engineering of Botulinum Neurotoxin A With Advanced Receptor Binding Affinity and Therapeutical Benefits

Advanced Science, EarlyView.
The butterfly unfolded wing in an open form structure of botulinum neurotoxin type A (BoNT/A) at physiological‐state was confirmed at 2.85 Å resolution by cryo‐electron microscopy (cryo‐EM). Structure‐guided protein engineering significantly enhanced the receptor‐binding affinity, therapeutic efficacy, and safety of the engineered toxin variants ...
Wenrui Wang, Zhaxi Zerang, Linjin You, Ziye Liu, Rong Nie, Fuwei Qi, Fenfen Gao, Chengmu Zhao, Wantong Ma, Jinghan He, Xiaoru Wang, Shanquan Wu, Bo Liu, Xinyao Liu, Dongsheng Lei, Dejuan Zhi, Dongsheng Wang   +16 more
wiley   +1 more source

Glial D-serine modulates oligodendrocyte lineage progression under inflammatory conditions. [PDF]

Front Cell Neurosci
Espinoza JP, Cisterna I, Triviño JJ, Arancibia V, Beltrán-Castillo S.   +4 more
europepmc   +1 more source

PET Imaging of Cardiac Inflammation in Viral Myocarditis Using a DPP4‐Targeted Probe

Advanced Science, EarlyView.
This study describes a DPP4‐targeted PET probe for imaging myocardial inflammation by selectively targeting activated immune cells. Derived from the clinically approved small‐molecule inhibitor linagliptin, the probe demonstrates favorable biodistribution with specific cardiac uptake in myocarditis.
Wanhao Gao, Wenzhu Hu, Du Tang, Xinxin Liu, Kun Yu, Lixia Feng, Minyu Liao, Wang Lin, Wenqiang Zhu, Sanjay Rajagopalan, Xiaoli Lan, Jixin Zhong, Dao Wen Wang, Dawei Jiang, Xiaoquan Rao   +14 more
wiley   +1 more source

Evidence of transfer of antimicrobial resistance genes from the porcine pathogen <i>Streptococcus suis</i> to human clinical isolates of <i>Streptococcus agalactiae</i> in a major pig-producing region of Spain. [PDF]

One Health
Uruén C, Lavilla MJ, Libante V, Marín CM, Rezusta A, Payot S, Arenas J.   +6 more
europepmc   +1 more source