Results 201 to 210 of about 652,471 (299)

Amino acids metabolism: a potential target for cancer treatment. [PDF]

Mol Cancer
Ren S, Zhou X, Wang Z, Yuan K.
europepmc   +1 more source

Aberrant SUMOylation Restricts the Targetable Cancer Immunopeptidome

Advanced Science, EarlyView.
Pharmacological SUMOylation inhibition (SUMOi) counteracts tumor immune evasion by unmasking an immunogenic HLA‐I peptide and neoepitope repertoire. By restoring HLA‐I ligand availability through increased antigen processing and presentation, enhanced proteasomal cleavage, and modulated TAP1 peptide affinity, SUMOi boosts tumor immunogenicity ...
Uta M. Demel, Anna Meurer, Badeel Kh. Q. Zaghla, Bilge Atay, Daniel Steiert, Luca V. Hummel, Konstandina Isaakidis, Chuanbing Zang, Michael Korenkov, Marlon Schielin, Schayan Yousefian, Shima Mecklenbräuker, Marieluise Kirchner, Simon Haas, Antonia Busse, Philipp Mertins, Stefan Müller, Matthias Wirth, Martin G. Klatt, Ulrich Keller   +19 more
wiley   +1 more source

An Alternative Metabolic Pathway of Glucose Oxidation Induced by Mitochondrial Complex I Inhibition: Serinogenesis and Folate Cycling. [PDF]

Int J Mol Sci
Abrosimov R, Borlepawar A, Hajieva P, Moosmann B.   +3 more
europepmc   +1 more source

The Structural Logic of Dynamic Signaling in the Escherichia coli Serine Chemoreceptor [PDF]

Georgina I. Reyes, Caralyn E. Flack, John S. Parkinson   +2 more
openalex   +1 more source

ALDOA‐Mediated Metabolic Reprogramming is a Targetable Vulnerability for Ferroptosis Sensitization in Cancer

Advanced Science, EarlyView.
ALDOA‐depletion‐mediated glycolytic reprogramming promotes autophagy‐mediated degradation of MBOAT2, increasing the ratio of phospholipids containing pro‐ferroptotic polyunsaturated fatty acids over anti‐ferroptotic monounsaturated fatty acids, and thus sensitizing cancer cells to ferroptosis.
Pengqi Wang, Kezhang He, Bowen Wang, Wei Zhou, Ying Zhang, Tianhua Ma, Sheng Ding   +6 more
wiley   +1 more source

XIAP down-regulation inhibits RIPK2 ubiquitination-mediated insulin resistance. [PDF]

Endocr Connect
Zhao C, Zhang Z, Li R, Geng X.
europepmc   +1 more source

Serine Rejuvenated Degenerated Volvariella volvacea by Enhancing ROS Scavenging Ability and Mitochondrial Function [PDF]

Qiao-Li Wang, Jianing Zhu, Yonghui Wang, Jianmin Yun, Yubin Zhang, Fengyun Zhao   +5 more
openalex   +1 more source

Lipid Droplet‐Localized Spindle Apparatus Coiled‐Coil Protein 1 Regulates Lipid Droplet Distribution

Advanced Science, EarlyView.
SPDL1‐L, a long isoform of SPDL1, is identified as a bona fide lipid droplet‐associated protein that acts as a dynein adaptor to drive perinuclear clustering of lipid droplets. By linking lipid droplets to the microtubule network, SPDL1‐L extends the function of SPDL1 beyond mitosis and contributes to lipid droplet organization and nuclear remodeling ...
Honggang Su, Huimin Pan, Yaqiang Liu, Wei Wang, Yang Jiao, Yumo Hang, Xiahe Huang, Yong E. Zhang, Yuhang Chen, Mei Ding, Xun Huang   +10 more
wiley   +1 more source

Effects of risperidone on amino acid metabolism, glucose, and kidney function in healthy adults: A pilot randomized controlled trial. [PDF]

PLoS One
Oshima M, Toyama T, Nakade Y, Miyagi S, Ogura H, Nakagawa S, Yuasa T, Koshino A, Horikoshi K, Minami T, Sako K, Tsuge S, Tamai A, Nishioka R, Miyagawa T, Ito K, Kitajima S, Mizushima I, Hara A, Sakai N, Shimizu M, Tokumaru T, Tsubomoto M, Kikuchi M, Kinoshita M, Nakada M, Mita M, Iwata Y, Wada T.   +28 more
europepmc   +1 more source