Results 211 to 220 of about 938,109 (291)

Purification and Properties of d-Serine Dehydrase from Escherichia coli

, 1966
Daniel Dupourque, W. Austin Newton, Esmond E. Snell   +2 more
openalex   +1 more source

Intestinal Epithelial‐Derived USP13 Alleviates Colonic Inflammation by Suppressing GRP78‐mediated Endoplasmic Reticulum Stress

Advanced Science, EarlyView.
USP13 deficiency in intestinal epithelial cells aggravates DSS‐induced colitis by enhancing ER stress and apoptosis. USP13 interacts with GRP78 and reduces its K63‐linked ubiquitination to alleviate epithelial injury. Restoring USP13 expression or targeting the USP13‐GRP78 axis may represent a promising strategy for treating inflammatory bowel disease ...
Chenchen Qian, Chenghong Hu, Yong Xu, Wentao Xu, Zhe Wang, Wan Gan, Weiyang Tang, Lijiang Huang, Aleksandr V. Samorodov, Yi Wang   +9 more
wiley   +1 more source

Phosphoglycerate dehydrogenase is required for kernel development and defines a predominant serine synthesis pathway in maize. [PDF]

Plant Cell
Zhang Y, Li R, Zheng D, Zhao J, Qing K, He R, Ma Z, Chen J, Xue N, Tian X, Wang E, Xu J, Li Y, Tan BC, Zhou Z, Wang C, Dong J.   +16 more
europepmc   +1 more source

NSP7 Molecular Degrader Attenuates Coronaviral Infection Through the β‐TrCP1/FBXO5 Axis

Advanced Science, EarlyView.
Host E3 ligase FBXO5 as a key regulator that promotes K48‐linked ubiquitination and proteasomal degradation of SARS‐CoV‐2 NSP7, thereby suppressing viral replication. NSP7 ubiquitination is co‐regulated by β‐TrCP1 and TAF1. Small molecule BC24877 disrupts β‐TrCP1‐mediated degradation of FBXO5, stabilizing FBXO5 and enhancing NSP7 clearance ...
Yao Tong, Travis B. Lear, Ferhan Tuncer, John J. Villandre, Áine N. Boudreau, Bo Lin, Irene Alfaras, Jason R. Kennerdell, Daniel P. Camarco, Mads B. Larsen, Yun Hua, Yanwen Chen, Meigin E. Chandler, Ricardo Pineda, Simon M. Barratt‐Boyes, John W. Evankovich, Toren Finkel, Yuan Liu, Bill B. Chen   +18 more
wiley   +1 more source

Serine-Driven Metabolic Plasticity Drives Adaptive Resilience in Pancreatic Cancer Cells. [PDF]

Antioxidants (Basel)
Bonanomi M, Mallia S, Scalise M, Aramini T, Baldassari F, Brivio E, Conte F, Lo Dico A, Bonas M, Porro D, Indiveri C, Metallo CM, Gaglio D.   +12 more
europepmc   +1 more source

MALMPS: A Machine Learning‐Based Metabolic Gene Prognostic Signature for Stratifying Clinical Outcomes and Molecular Heterogeneity in Stage II/III Colorectal Cancer

Advanced Science, EarlyView.
Chen et al. identified a metabolic gene prognostic signature with machine‐learning framework and assessed the prognostic value in independent CRC cohorts. The metabolic signature subtypes are characterized by specific metabolic and proteomic characteristics, and associated with distinct molecular pathway and therapeutic potential.
Hao Chen, Ze Wang, Chenglong Sun, Yang Zhong, Yuan Liu, Yikun Li, Tongchao Zhang, Yuan Zhang, Xingyu Zhu, Leping Li, Feifei Teng, Ming Lu, Wei Chong   +12 more
wiley   +1 more source

Amino acid metabolism in breast cancer: pathogenic drivers and therapeutic opportunities. [PDF]

Protein Cell
Liu Y, Zong X, Altea-Manzano P, Fu J.
europepmc   +1 more source

Serine Transhydroxymethylase

, 1964
LaVerne Schirch, W. Terry Jenkins
openalex   +1 more source

Ubiquitination‐Dependent LLGL2 Degradation Drives Colorectal Cancer Progression via THBS3 mRNA Stabilization

Advanced Science, EarlyView.
During the progression of CRC, MDM2, as an E3 ubiquitin ligase, promotes the degradation of the LLGL2 protein. Reduced expression of the LLGL2 protein leads to the loss of support for the CNOT1 protein, decreasing the degradation of THBS3 mRNA. The increased THBS3 further activates the PI3K‐Akt pathway, promoting the proliferation and metastasis of CRC.
Jiayan Huang, Tiantian Zhang, Huimin Li, Zidan Li, Shuangshuang Yin, Yiman Liu, Chunze Zhang, Yuling Qiu, Haiyang Yu   +8 more
wiley   +1 more source

Unveiling Hidden Intramolecular Non-Covalent Interactions in a Neutral Serine, Its Zwitterion, Cluster, and Crystal by Features of Electron Density. [PDF]

J Comput Chem
Korotenko V, Egorova A, Tsirelson V.
europepmc   +1 more source