Results 311 to 320 of about 951,429 (338)

Microbial metabolism mediates the deteriorative effects of sedentary behaviour on insulin resistance. [PDF]

Clin Transl Med
Ju J, He J, Ye B, Li S, Zhao J, Chen W, Zhang Q, Zhao W, Yang J, Liu L, Li Y, Xia M, Liu Y.   +12 more
europepmc   +1 more source

SLC1A4 and Serine Homeostasis: Implications for Neurodevelopmental and Neurodegenerative Disorders. [PDF]

Int J Mol Sci
Elazar D, Alvarez N, Drobeck S, Gunn TM.
europepmc   +1 more source

High-throughput amino acid-level characterization of the interactions of plasminogen activator inhibitor-1 with variably divergent proteases. [PDF]

Protein Sci
Haynes LM, Holding ML, DiGiovanni HL, Siemieniak D, Ginsburg D.   +4 more
europepmc   +1 more source

Exogenous L-Serine Alleviates <i>Pasteurella multocida</i>-Induced Inflammation by Reprogramming the Transcription and Metabolism of Macrophages. [PDF]

Vet Sci
He F, Lang Z, Huang Y, Qiu Y, Xiong P, Li N, Zhao G, Peng Y.   +7 more
europepmc   +1 more source

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Mechanism of eukaryotic serine racemase-catalyzed serine dehydration

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2020
Eukaryotic serine racemase (SR) is a pyridoxal 5'-phosphate enzyme belonging to the Fold-type II group, which catalyzes serine racemization and is responsible for the synthesis of D-Ser, a co-agonist of the N-methyl-d-aspartate receptor. In addition to racemization, SR catalyzes the dehydration of D- and L-Ser to pyruvate and ammonia.
Hisashi Hemmi, Masaru Goto, Tomokazu Ito, Tohru Yoshimura, Ryoma Nasu, Soichiro Watanabe, Kazuma Matsushita, Taichi Mizobuchi, Mai Matsuoka   +8 more
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Reactions of Serine Palmitoyltransferase with Serine and Molecular Mechanisms of the Actions of Serine Derivatives as Inhibitors

Biochemistry, 2004
Serine palmitoyltransferase (SPT) is a key enzyme in sphingolipid biosynthesis and catalyzes the decarboxylative condensation of L-serine and palmitoyl coenzyme A to 3-ketodihydrosphingosine. We have succeeded in the overproduction of a water-soluble homodimeric SPT from Sphingomonas paucimobilis EY2395(T) in Escherichia coli.
Hiroyuki Kagamiyama, Hideyuki Hayashi, Hiroko Ikushiro   +2 more
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Synthesis of photodeprotectable serine derivatives. “Caged serine”

Bioorganic & Medicinal Chemistry Letters, 1992
Abstract The synthesis of O-(4,5-dimethoxy-2-nitrobenzyl)serine has been accomplished by treatment of an FMOC-aziridinecarboxylate with nitroveratryl alcohol followed by hydrolysis. Irradiation with a Pyrex-filtered 450W Hanovia lamp releases serine with a half-life of 4.4 min. o-Nitrobenzyl serinate is prepared by direct esterification.
David S. Nunn, Michael C. Pirrung
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KAHA Ligation at Serine

ChemBioChem, 2015
Oxazetidine assisted KAHA ligation was developed by the Bode group as an efficient peptide segment ligation strategy at native serine residues. This milestone achievement should enable the chemical synthesis of difficult-to-prepare proteins for biological studies.
Lei Liu, Yi-Chao Huang, Yi-Ming Li
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On the nucleophilicity of serine in enzymes

Journal of Theoretical Biology, 1968
Abstract Certain anionic nucleophiles containing cationic groups possess higher reactivities in displacement reactions with neutral substrates than would be predicted from their aqueous basicities. The explanation for this behavior has been applied to show how the serine moiety in an enzyme with, perhaps, relatively small assistance from a ...
W.A. Mosher, J. Epstein, H.O. Michel
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Serine racemase and the serine shuttle between neurons and astrocytes

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2011
d-Serine is a brain-enriched d-amino acid that works as a transmitter-like molecule by physiologically activating NMDA receptors. Synthesis of d-serine is carried out by serine racemase (SR), a pyridoxal 5'-phosphate-dependent enzyme. In addition to carry out racemization, SR α,β-eliminates water from l- or d-serine, generating pyruvate and NH(4 ...
openaire   +3 more sources