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Serine hydroxymethyltransferase revisited
Current Opinion in Chemical Biology, 2005Recent structural data and the properties of several active site mutants of serine hydroxymethyltransferase have resolved some key questions concerning the catalytic mechanism and broad substrate specificity of this enzyme. In the tetrahydrofolate-dependent conversion of serine to glycine, an early proposed mechanism involved a retroaldol cleavage and ...
Verne Schirch, Doletha M. E. Szebenyi
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Crystallization of serine carboxypeptidases
Journal of Molecular Biology, 1990Crystallization of three different serine carboxypeptidases has been achieved by the method of hanging-drop vapor diffusion. Serine carboxypeptidases II from wheat bran and malted barley crystallize isomorphously from polyethylene glycol solutions at room temperature (pH 4 to 7) in space group P4(1)2(1)2 or enantiomorph with cell dimensions of a = b ...
Klaus Breddam +4 more
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Journal of Chemical Theory and Computation, 2016
The myriad conformers of the neutral form of natural amino acid serine (Ser) have been investigated by systematic computations with reliable electronic wave function methods. A total of 85 unique conformers were located using the MP2/cc-pVTZ level of theory.
Kedan He, Wesley D. Allen
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The myriad conformers of the neutral form of natural amino acid serine (Ser) have been investigated by systematic computations with reliable electronic wave function methods. A total of 85 unique conformers were located using the MP2/cc-pVTZ level of theory.
Kedan He, Wesley D. Allen
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Serine metabolism and psychosis
Psychiatry Research, 1984Plasma serine levels (PSL) in a group of patients with the diagnosis of major or atypical psychoses were significantly higher than in patients with nonpsychotic diagnoses or nonpatient controls. The enzyme serine hydroxymethyltransferase (SHMT), which metabolizes serine to glycine, showed abnormal activity in the psychotics compared to nonpsychotics ...
Rafiq Waziri +3 more
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An Overview of Serine Proteases [PDF]
Current Protocols in Protein Science, 2001 AbstractThis unit summarizes the families of serine proteases and their mechanism of catalysis. Methods for assays and determining substrate specificity are briefly described. The mode of action of commonly available inhibitors is also included.
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Current Opinion in Neurology, 2004
Serine-deficiency disorders comprise a new group of neurometabolic diseases and are caused by defects in the biosynthesis of the amino acid L-serine. In contrast to most neurometabolic disorders, serine-deficiency disorders are potentially treatable. Furthermore, the severe neurological symptoms observed in patients underscore the important roles of ...
Tom J. de Koning, Leo W. J. Klomp
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Serine-deficiency disorders comprise a new group of neurometabolic diseases and are caused by defects in the biosynthesis of the amino acid L-serine. In contrast to most neurometabolic disorders, serine-deficiency disorders are potentially treatable. Furthermore, the severe neurological symptoms observed in patients underscore the important roles of ...
Tom J. de Koning, Leo W. J. Klomp
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Refolding of serine proteinases
Journal of Cellular Biochemistry, 1986AbstractBovine trypsinogen and chymotrypsinogen were successfully refolded as the mixed disulfide of glutathione using cysteine as the disulfide interchange catalyst. The native structures were regenerated with yields of 40%–50% at pH 8.6 and 4 °C, and the half‐time for the refolding was approximately 60–75 min.
Chester T. Duda +3 more
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Homologies in serine proteinases
Philosophical Transactions of the Royal Society of London. B, Biological Sciences, 1970Bovine pancreatic juice contains approximately equal amounts of four inactive precursors of endopeptidases (zymogens): chymotrypsinogen A, chymotrypsinogen B, trypsinogen (Keller, Cohen & Neurath 1958) and a component of procarboxypeptidase which resembles a chymotrypsinogen (Brown, Greenshields, Yamasaki & Neurath 1963).
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PEGylated d-serine dehydratase as a d-serine reducing agent
Journal of Pharmaceutical and Biomedical Analysis, 2015D-Serine is an endogenous coagonist for N-methyl-D-aspartate (NMDA) receptors and is involved in excitatory neurotransmission. Excessive receptor activation causes excitotoxicity, leading to various acute and chronic neurological disorders. Decrease in D-serine content may provide a therapeutic strategy for the treatment of the neurological disorders ...
Tsukasa Matsuda +8 more
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Immunomodulation by Serine Phospholipids
1993When the body is under threat from invading pathogens or other type of injury, local cell populations initiate a coordinated defense program, known as the inflammatory response. The first wave of signalling molecules causes vasodilation and the expression of leukocyte-endothelial cell adhesion molecules, directing the migration of circulating cells ...
Bruni A. +4 more
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