Results 161 to 170 of about 245,013 (288)

Modulating Integrin and Growth Factor Signaling With Peptides: Strategies to Synergistically Enhance Bone Tissue Regeneration

Advanced Science, EarlyView.
It has been demonstrated that, in the bone extracellular matrix (ECM), integrins and growth factor receptors (GFRs) engage in synergistic signaling to guide bone healing and regeneration. This review provides a comprehensive overview of current strategies using ECM‐derived peptides to recreate the cellular microenvironment and harness synergistic ...
Lluís Oliver‐Cervelló, Elisabetta Ada Cavalcanti‐Adam, Carlos Mas‐Moruno   +2 more
wiley   +1 more source

C1 metabolism, the serine cycle and mixed acid fermentation in A. macleodii ATCC 27126.

Daniel Sher (95556), Emma E. George (6786845), Matthias Wietz (6473840), Scott Gifford (21175699), Luca Zoccarato (8120336), Osnat Weissberg (21175702), Coco Koedooder (5999399), Waseem Bashir Valiya Kalladi (21175705), Marcelo M. Barreto Filho (11176278), Raul Mireles (21175708), Stas Malavin (20912885), Michal Liddor Naim (21175711), Tal Idan (9741896), Vibhaw Shrivastava (21175714), Lynne Itelson (21175717), Dagan Sade (21175720), Alhan Abu Hamoud (21175723), Yara Soussan-Farhat (21175726), Noga Barak (15081120), Peter Karp (450757), Lisa R. Moore (3313833)   +20 more
openalex   +1 more source

Reprogramming of serine, glycine and one-carbon metabolism in cancer

, 2020
Albert M. Li, Jiangbin Ye
openalex   +2 more sources

PFOS Disrupts Oocyte Maturation and Early Embryonic Development via Ovarian FOXK1 O‐GlcNAcylation in Mice

Advanced Science, EarlyView.
Perfluorooctane sulfonate (PFOS) exposure disrupts oocyte maturation and early embryonic development. This study elucidates the mechanism by which enhanced O‐GlcNAcylation of FOXK1 underlies the PFOS‐induced reduction of progesterone levels in granulosa cells and the disturbance of follicular microenvironment.
Shuwen Han, Qin Yuan, Zhu Wu, Yaohui Fang, Hong Qian, Jiale Zhu, Yuchen Zhang, Ke Deng, Liangliang Su, Haibo Xu, Haotian Shu, Yiming Gong, Qiaoqiao Xu, Guizhen Du, Di Wu, Yun Fan, Chuncheng Lu   +16 more
wiley   +1 more source

PHGDH-dependent serine metabolism in astrocytes: A key regulator of oxidative stress and pyroptosis in cerebral ischemia-reperfusion injury. [PDF]

Redox Biol
Zhang J, Luo Y, Xie C, Zhang M, Qin H, Zhou Y, Wu X, Hu C, Hu F, Fei X, Zhang H, Li J, Fu Y, Yuan Y, Yang S, Gao D.   +15 more
europepmc   +1 more source

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

The Parkinson's disease-associated LRRK2-G2019S variant restricts serine metabolism, leading to microglial inflammation and dopaminergic neuron degeneration. [PDF]

J Neuroinflammation
Kurniawan H, Nickels SL, Zagare A, Zuccoli E, Rosety I, Gomez-Giro G, Glaab E, Schwamborn JC.   +7 more
europepmc   +1 more source

CircMYH9 drives colorectal cancer growth by regulating serine metabolism and redox homeostasis in a p53-dependent manner. [PDF]

Mol Cancer, 2021
Liu X, Liu Y, Liu Z, Lin C, Meng F, Xu L, Zhang X, Zhang C, Zhang P, Gong S, Wu N, Ren Z, Song J, Zhang Y.   +13 more
europepmc   +1 more source

GbWAKL20 Phosphorylates GbNFYB8 to Modulate Verticillium Wilt Resistance in Cotton

Advanced Science, EarlyView.
Wall‐associated receptor‐like kinases (WAKLs) play pivotal roles in extracellular–intracellular signal transduction. Upon sensing Verticillium dahliae infestation at the plasma membrane, GbWAKL20 accumulates and transmits signals to the nucleus via endoplasmic reticulum‐mediated Golgi vesicle transport.
Guilin Wang, Qingxin Si, Zhiguo Chen, Zhe Yu, Zhan Guo, Lu Wang, Weixi Li, Wangzhen Guo   +7 more
wiley   +1 more source

eLife Assessment: Phosphoglycerate mutase regulates Treg differentiation through control of serine synthesis and one-carbon metabolism

Sameh Ali
openalex   +1 more source