Results 141 to 150 of about 265,042 (263)

T2T Genome Assembly and Multi‐Omics Data Reveal Terrestrial Adaptation and Mucus Biosynthesis in Tropical Leatherleaf Slug (Laevicaulis alte)

Advanced Science, EarlyView.
A gap‐free genome assembly and multi‐omics comparison of the terrestrial slug Laevichaulis alte with an aquatic relative reveal that expansion of the VEGF family orchestrates mucus production, lipid metabolism, and immune defense—highlighting key molecular innovations for conquering life on land.
Gang Wang, Shaofang He, Zhongkai Wang, Aobo Pang, Xiaoli Sun, Rongchen Liu, Fang Wang, Sisi Chen, Zhijuan Bian, Dongcheng Wei, Liuhan Wu, Siyao Zhao, Qiuting Ji, Yiqi Sun, Niying Sun, Yushinta Fujaya, Boping Tang, Kianann Tan, Daizhen Zhang, Lianfu Chen   +19 more
wiley   +1 more source

Serine protease HtrA promotes <i>Campylobacter jejuni</i> intestinal colonization through degrading antimicrobial peptide LL-37. [PDF]

Sci Adv
Li X, Zhang M, Xu Z, Li Y, Bian S, Tang Y, Jiao X, Gundogdu O, Huang J.   +8 more
europepmc   +1 more source

NAD+ Metabolism Licenses Zygotic Genome Activation via PARP7‐Mediated ADP‐Ribosylation of UHRF1 in Mouse Early Embryos

Advanced Science, EarlyView.
This study uncovers a metabolic‐epigenetic axis licensing zygotic genome activation (ZGA) in mouse embryos. A developmental decline in NAD+ levels activates PARP7, which mono‐ADP‐ribosylates and stabilizes UHRF1. This modification promotes the establishment of permissive histone acetylation marks, thereby facilitating timely ZGA.
Guangyi Cao, Ziqi Zhang, Anqi Chen, Yanbo Liu, Yuling Lin, Lina Yu, Ruixin Shi, Aolei Guo, Yan Mao, Ganggui Lou, Chaojun Li, Luhong Wen, Guijun Yan, Haixiang Sun   +13 more
wiley   +1 more source

A Trypsin-Like Serine Protease ZmNAL1a Fine-Tunes Maize Floral Transition and Flowering Time. [PDF]

Adv Sci (Weinh)
Li N, Ning Q, Li Z, Zhang Q, Zhu P, Zhan J, Li Y, Li Z, Dong L, Xiong Q, Liao J, Liu J, Jackson D, Kitagawa M, Zhang Z, Liu L.   +15 more
europepmc   +1 more source

Pericentrosomal Redistribution of the Endoplasmic Reticulum Ensures Organelle Symmetric Inheritance and Mitotic Progression

Advanced Science, EarlyView.
Upon mitotic entry, RTN4 relocalizes to the pericentrosomal region, forming a more tubular ER network around centrosomes. CDK1‐mediated phosphorylation of RTN4 increases its interaction with Rab11 GTPase, facilitating dynein‐dependent transport of RTN4 to the pericentrosomal region.
Xiangyu Xu, Yalin Liu, Rongyi Wang, Wenwen Xu, Hao Shi, Ning Huang, Junlin Teng, Jin Meng, Pengli Zheng, Jianguo Chen   +9 more
wiley   +1 more source

Comprehensive Analyses of Serine Protease-like Protease (SBT) in Regulating Yield Characters in Rapeseed (<i>Brassica napus</i> L.). [PDF]

Plants (Basel)
Shi X, Lei Q, Xiang S, Lu K, Qu C, Li J, Zhang L.   +6 more
europepmc   +1 more source

Analyses of serine proteases and serine protease inhibitors : Evolutionary and structural insights

, 2012
Analyses of proteases and protease inhibitorsProteolytic enzymes (also known as proteases, proteinases) are enzymes capable of proteolysis (breakdown of proteins), by hydrolysis of the peptide bonds that link amino acids in a polypeptide chain. There are different types of proteases that are found to be important in various biological functions, such ...
openaire   +1 more source

RBM12 Maintains Glioma Stem Cells by Activating Amino Acid‐Dependent mTORC1 Signaling via SLC7A5 mRNA Stabilization

Advanced Science, EarlyView.
This study shows that in glioma stem cells (GSCs), RBM12 recruits ALKBH5 to remove m6A from SLC7A5 transcripts, thereby enhancing mRNA stability, which elevates large neutral amino acid (LNAA) levels and activates mTORC1, promoting GSC proliferation, self‐renewal, and tumor growth.
Hong Lei, Wenlong Luo, Shu Zhou, Lihao Wan, Peng Ling, Zhihua Huang, Zhihua Qian, Chenfei Lu, Mengyue Guo, Zhen Xue, Jun Qin, Ningwei Zhao, Jianghong Man, Wenchao Zhou, Zhiqiang Dong, Shutong Xu, Zhipeng Zhou, Xiuxing Wang, Weiwei Tao   +18 more
wiley   +1 more source

Serine Protease HtrA2 from Halophilic Archeon <i>Haloarcula</i> sp. TG1: Heterologous Expression, Characterization and Immobilization. [PDF]

Biomolecules
Kurt-Kızıldoğan A, Konuksever Ö, Yavuz Ö, Otur Ç, Abanoz-Seçgin B, Okay S.   +5 more
europepmc   +1 more source

Biomimetic Nanoplatform for Dual Target Nano‐Metabolic Therapy in Diabetes‐Associated Biofilm Infections

Advanced Science, EarlyView.
A biomimetic GOx/Arg‐loaded nanoplatform produces nitric oxide through an in situ catalytic cascade reaction, enabling dual‐target metabolic regulation in diabetes‐associated biofilm infections. Bacterial metabolism is disrupted, and macrophage immunometabolism is reprogrammed, resulting in biofilm eradication, immune restoration, and enhanced ...
Mingzhang Li, Yonglong Li, Jiren Yan, Changming Wang, Jinlong Yu, Feng Jiang, Boyong Wang, Yi Yang, Deyi Ding, Jin Tang, Pei Han, Botao Song, Geyong Guo, Hao Shen   +13 more
wiley   +1 more source