Results 271 to 280 of about 372,460 (343)

Advancing the Exploration of the Ubiquitin‐like Protein FUBI with Synthetic Chemical Tools

ChemBioChem, EarlyView.
This study unveils a novel synthetic platform by solid‐phase peptide synthesis for generating FUBI‐based chemical tools to investigate FUBIylation, a poorly understood ubiquitin‐like signaling process linked to cancer. By employing these innovative probes, we uncover novel FUBI interactors, paving the way for transformative insights into FUBI biology ...
Francesca D’Amico, Cami M. P. Talavera Ormeño, Shivanganie Poeran, Jimmy Akkermans, Rayman T. N. Tjokrodirijo, Bharath Sampadi, Peter van Veelen, Aysegul Sapmaz, Monique P. C. Mulder   +8 more
wiley   +1 more source

Microsporidian Nosema bombycis secretes serine protease inhibitor to suppress host cell apoptosis via Caspase BmICE. [PDF]

PLoS Pathog
Ran M, Bao J, Li B, Shi Y, Yang W, Meng X, Chen J, Wei J, Long M, Li T, Li C, Pan G, Zhou Z.   +12 more
europepmc   +1 more source

Inhibition of endosome-lysosome system acidification enhances porcine circovirus 2 infection of porcine epithelial cells [PDF]

, 2008
Delputte, Peter, Misinzo, Gerald, Nauwynck, Hans   +2 more
core  

C13‐Deacylase from Nocardioides albus Resp. Streptomyces sp., Catalyzing Side Chain Hydrolysis on the Taxane Core

ChemCatChem, EarlyView.
An enzyme that has been identified and characterized as capable of hydrolyzing paclitaxel (Taxol), a key anticancer drug derived from Pacific yew (Taxus brevifolia) has been identified. Molecular docking (MD) simulations map the catalytic triad and critical residues that drive substrate‐enzyme interactions. The findings indicate the catalytic potential
Jinfen Su, Eugen Schell, Thomas Heine, Marion B. Ansorge‐Schumacher   +3 more
wiley   +1 more source

Nematode serine protease inhibitor SPI-I8 negatively regulates host NF-κB signalling by hijacking MKRN1-mediated polyubiquitination of RACK1. [PDF]

Commun Biol
Wu F, Chen Y, Chen X, Tong D, Zhou J, Du Z, Yao C, Yang Y, Du A, Ma G.   +9 more
europepmc   +1 more source

Inhibition of Amyloid β-Protein Production in Neural Cells by the Serine Protease Inhibitor AEBSF

, 1996
Martin Citron, Thekla S. Diehl, Anja Capell, Christian Haass, David B. Teplow, Dennis J. Selkoe   +5 more
openalex   +1 more source

Advancing Biocatalysis: Using Siloxanes to Solubilize and Stabilize Enzymes in Organic Solvents

ChemCatChem, EarlyView.
Biocatalysis offers an attractive route in the development of more sustainable approaches in silicon chemistry. Given the propensity for enzymes to operate optimally in an aqueous environment there are obvious challenges to incorporating biocatalysts in organic solvents.
Najibeh Alizadeh, Zain Ahmed, Paul M. Zelisko   +2 more
wiley   +1 more source

Transmembrane serine protease 4 expression in the prognosis of radical resection for biliary tract cancer. [PDF]

World J Gastrointest Surg
Shibata Y, Sudo T, Tazuma S, Tanimine N, Onoe T, Shimizu Y, Yamaguchi A, Kuraoka K, Takahashi S, Tashiro H.   +9 more
europepmc   +1 more source

Sequence analysis and regulation of a gene encoding a cuticle-degrading serine protease from the nematophagous fungus Arthrobotrys oligospora

, 1996
Jens Åhman, Bo Ek, Lars Rask, Anders Tunlid   +3 more
openalex   +1 more source

Epigenetic Changes Related to Hypertension in Asian Adults: A Systematic Review

Chronic Diseases and Translational Medicine, EarlyView.
PRISMA study flow diagram. ABSTRACT Background Elevated high blood pressure is controlled by complicated, little‐understood genetic and epigenetic pathways that are influenced by both heritable and environmental variables. Many adult systolic and diastolic blood pressure‐related genomic loci have been identified through previous genome‐wide association
Lilik Sukesi, Yunia Sribudiani, Steven Yulius Usman, Eric Ricardo Yonatan, Ahmedz Widiasta, Noormarina Indraswari, Ria Bandiara, Nanny N. M. Soetedjo   +7 more
wiley   +1 more source