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Rare Disease and Orphan Drugs Journal, 2023
The identification and characterization of the four active neutrophil serine proteases (NSPs) have provided a better understanding of their roles in various physiological and pathological processes. The availability of appropriate tools such as substrates, inhibitors, and activity-based probes (ABPs) for studying their activity and functions in cells ...
Marcin Skoreński +2 more
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The identification and characterization of the four active neutrophil serine proteases (NSPs) have provided a better understanding of their roles in various physiological and pathological processes. The availability of appropriate tools such as substrates, inhibitors, and activity-based probes (ABPs) for studying their activity and functions in cells ...
Marcin Skoreński +2 more
openaire +1 more source
Novel Serine Protease Inhibitors
Pharmaceutical Patent Analyst, 2012The pursuit of serine protease inhibitors as anticoagulants and anti-hepatitis C virus drugs continues to be an active area of research. Compounds such as P1-P3 macrocyclic peptides and linear peptides have been registered as potent hepatitis C virus protease inhibitors and compounds such as phenylglycinamide derivatives, substituted biaryls ...
Anilkumar R, Kore +1 more
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Serpins (Serine Protease Inhibitors)
Current Protocols in Protein Science, 2001AbstractSerpins are a class of proteins involved in the regulation of serine and other types of proteases. In humans, the majority of serpins regulate the functions of proteases involved in the body's response to injury. This includes roles in coagulation, fibrinolysis, inflammation, wound healing, and tissue repair.
Susannah J, Bauman +2 more
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Serine protease inhibitors (serpins)
Trends in Cardiovascular Medicine, 1991Inhibition of serine proteases by serpins (serpin: serine protease inhibitor) is a key mechanism for the control of proteolysis in thrombosis, shock, and inflammation. The various members of the serpin gene superfamily (α(1)-antitrypsin, ovalbumin, C1-inhibitor, antithrombin III, α(2)-antiplasmin, type-1 plasminogen-activator inhibitor, and so forth ...
M, Schapira, P A, Patston
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Type II transmembrane serine proteases
Thrombosis and Haemostasis, 2003SummaryThe recent availability of human and mouse genome sequences and expressed sequence tag databases facilitated the identification of a large new family of membrane anchored serine proteases, the type II transmembrane serine proteases or TTSPs.
Roman, Szabo +5 more
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Targeting Serine Proteases in Asthma
Current Topics in Medicinal Chemistry, 2006Leukocytes and lung structural cells contribute to the pathophysiology of asthma through the production of numerous mediators including serine proteases. Such proteases include mast cell tryptase and chymase; neutrophil elastase, cathepsin G and myeloblastin (proteinase 3); bronchial epithelial cell-derived transmembrane protease, serine 11D (human ...
Caroline, Guay +2 more
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Genomic overview of serine proteases
Biochemical and Biophysical Research Communications, 2003Serine proteases (SP) are peptidases with a uniquely activated serine residue in the substrate-binding pocket. They represent about 0.6% of all proteins in the human genome. SP are involved in many vital functions such as digestion, blood clotting, fibrinolysis, fertilization, and complement activation and are related to many diseases including cancer,
George M, Yousef +3 more
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